Edonamides, the first secondary metabolites from the recently described myxobacterium Aggregicoccus edonensis

被引：3

作者：

Karwehl, Sabrina ^{[1
,2
]}

Mohr, Kathrin I. ^{[1
,2
]}

Jansen, Rolf ^{[1
,2
]}

Sood, Sakshi ^{[1
]}

Bernecker, Steffen ^{[1
,2
]}

Stadler, Marc ^{[1
,2
]}

机构：

[1] Helmholtz Ctr Infect Res, Dept Microbial Drugs, D-38124 Braunschweig, Germany

[2] German Ctr Infect Res DZIF, Partner Site Hannover Braunschweig, Braunschweig, Germany

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 46期

关键词：

Myxobacteria; DSM 27872(T); Secondary metabolites; Styrylamide; NMR; SORANGIUM-CELLULOSUM MYXOBACTERIA; MYXOCOCCUS-XANTHUS; GLIDING BACTERIA; ANTIFUNGAL; ANTIBIOTICS; PSEUDOMONAS; INHIBITOR; MECHANISM; GROWTH; FRAGIN;

D O I：

10.1016/j.tetlet.2015.09.139

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two fatty acid styryl amides, edonamides A (1) and B (2), were isolated as the first secondary metabolites from the recently described myxobacterial genus and family Aggregicoccus edonensis. Their molecular structures were elucidated using extensive HRESIMS and NMR analyses. Since edonamides A (1) and B (2) did not show inhibitory activity against different bacteria, fungi, and cell lines a role as signaling molecules in the life cycle of myxobacteria seems possible. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：6402 / 6404

页数：3

共 23 条

[1] Baumann, 2014, ANGEW CHEM, V126, P14835
[2] Straight-chain fatty acids are dispensable in the myxobacterium Myxococcus xanthus for vegetative growth and fruiting body formation
Bode, Helge B.
Ring, Michael W.
Kaiser, Dale
David, Anna C.
Kroppenstedt, Reiner M.
Schwaer, Gertrud
[J]. JOURNAL OF BACTERIOLOGY, 2006, 188 (15) : 5632 - 5634
[3] MM-55266 AND MM-55268, GLYCOPEPTIDE ANTIBIOTICS PRODUCED BY A NEW STRAIN OF AMYCOLATOPSIS - ISOLATION, PURIFICATION AND STRUCTURE DETERMINATION
BOX, SJ
COATES, NJ
DAVIS, CJ
GILPIN, ML
HOUGEFRYDRYCH, CSV
MILNER, PH
[J]. JOURNAL OF ANTIBIOTICS, 1991, 44 (08) : 807 - 813
[4] Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase
Chung, Jiwoung
Goo, Eunhye
Yu, Sangheon
Choi, Okhee
Lee, Jeehyun
Kim, Jinwoo
Kim, Hongsup
Igarashi, Jun
Suga, Hiroaki
Moon, Jae Sun
Hwang, Ingyu
Rhee, Sangkee
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (29) : 12089 - 12094
[5] ANTIBIOTICS FROM GLIDING BACTERIA .14. THE MYXALAMIDS, NEW ANTIBIOTICS FROM MYXOCOCCUS-XANTHUS (MYXOBACTERALES) .1. PRODUCTION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES, AND MECHANISM OF ACTION
GERTH, K
JANSEN, R
REIFENSTAHL, G
HOFLE, G
IRSCHIK, H
KUNZE, B
REICHENBACH, H
THIERBACH, G
[J]. JOURNAL OF ANTIBIOTICS, 1983, 36 (09) : 1150 - 1156
[6] Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria) - Production, physico-chemical and biological properties
Gerth, K
Bedorf, N
Hofle, G
Irschik, H
Reichenbach, H
[J]. JOURNAL OF ANTIBIOTICS, 1996, 49 (06) : 560 - 563
[7] THE SORAPHENS - A FAMILY OF NOVEL ANTIFUNGAL COMPOUNDS FROM SORANGIUM-CELLULOSUM (MYXOBACTERIA) .1. SORAPHEN A(1-ALPHA) - FERMENTATION, ISOLATION, BIOLOGICAL PROPERTIES
GERTH, K
BEDORF, N
IRSCHIK, H
HOFLE, G
REICHENBACH, H
[J]. JOURNAL OF ANTIBIOTICS, 1994, 47 (01) : 23 - 31
[8] SULFUR-CONTAINING AMIDES FROM GLYCOSMIS SPECIES WITH DIFFERENT ANTIFUNGAL ACTIVITY
GREGER, H
ZECHNER, G
HOFER, O
HADACEK, F
WURZ, G
[J]. PHYTOCHEMISTRY, 1993, 34 (01) : 175 - 179
[9] THE MECHANISM OF ACTION OF MYXOVALARGIN-A, A PEPTIDE ANTIBIOTIC FROM MYXOCOCCUS-FULVUS
IRSCHIK, H
REICHENBACH, H
[J]. JOURNAL OF ANTIBIOTICS, 1985, 38 (09) : 1237 - 1245
[10] DISORAZOL-A, AN EFFICIENT INHIBITOR OF EUKARYOTIC ORGANISMS ISOLATED FROM MYXOBACTERIA
IRSCHIK, H
JANSEN, R
GERTH, K
HOFLE, G
REICHENBACH, H
[J]. JOURNAL OF ANTIBIOTICS, 1995, 48 (01) : 31 - 35

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