Treatment of Cutaneous Injuries of Neonates Induced by Drug Extravasation with Hyaluronidase and Hirudoid

被引：2

作者：

Yan, Ya-Min ^{[1
]}

Fan, Qiao-Ling ^{[1
]}

Li, Ai-Qiu ^{[2
]}

Chen, Jia-Ling ^{[3
]}

Dong, Fei-Fei ^{[4
]}

Gong, Mei ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Neonatal Dept, Shanghai 200030, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Dept Nursing, Shanghai 200030, Peoples R China

[3] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Pediat Intens Care Unit, Shanghai 200030, Peoples R China

[4] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Cardiac Intens Care Unit, Shanghai 200030, Peoples R China

来源：

IRANIAN JOURNAL OF PEDIATRICS | 2014年 / 24卷 / 04期

关键词：

Treatment; Drug Extravasation; Hyaluronidase; Hirudoid; Neonate; INTRAVENOUS EXTRAVASATION; MANAGEMENT; INFILTRATION; RISK;

D O I：

暂无

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective: To analyze the effects of hyaluronidase and hirudoid treatment on drug extravasation in neonates. Methods: The medical records of 13 neonates with drug extravasation treated with hyaluronidase and hirudoid between August 1, 2010 and May 1st, 2012 were analyzed retrospectively. The treatment procedure for drug extravasation adhered to the protocol in neonatal department. The information including age, sex, weight, diagnosis, size of affected area, site of extravasation and treatment was collected. Findings: The extravasation injuries alleviated and the symptoms improved after treatment, no adverse drug effects were reported with use of hyaluronidase and hirudoid. Conclusion: The treatment appeared to be beneficial in the management of extravasations of various medications in neonates and may be useful in reducing the severity of cutaneous toxicosis. However, further studies with large samples are still needed to assess the effectiveness and safety of hyaluronidase and hirudoid.

引用

页码：352 / 358

页数：7

共 41 条

[1]

Banta C, 1992, Neonatal Netw, V11, P103

[2] NURSING MANAGEMENT OF ADRIAMYCIN EXTRAVASATION [J].