Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial-associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report

被引：1

作者：

Tanaka, Ryota ^{[1
]}

Matsumoto, Asami ^{[1
]}

Tatsuta, Ryosuke ^{[1
]}

Ando, Tadasuke ^{[2
]}

Shin, Toshitaka ^{[2
]}

Mimata, Hiromitsu ^{[2
]}

Itoh, Hiroki ^{[1
]}

机构：

[1] Oita Univ Hosp, Dept Clin Pharm, Yufu, Oita 8795593, Japan

[2] Oita Univ, Fac Med, Dept Urol, Oita, Japan

来源：

CLINICAL CASE REPORTS | 2022年 / 10卷 / 06期

关键词：

antimicrobial-associated diarrhea; broad-spectrum antibiotics; enterohepatic circulation; mycophenolic acid; CYCLOSPORINE; TACROLIMUS; MOFETIL; CURVE; AREA;

D O I：

10.1002/ccr3.5914

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mycophenolic acid (MPA) undergoes enterohepatic circulation. A kidney transplant patient on mycophenolate mofetil was treated with tazobactam/piperacillin for pyelonephritis, and developed antimicrobial-associated diarrhea. Consequently, the MPA trough level decreased by approximately 90%. Furthermore, it took approximately a month for the MPA level to normalize even after diarrhea had resolved.

引用

页数：6