Associations Between Prediabetes, by Three Different Diagnostic Criteria, and Incident CVD Differ in South Asians and Europeans

被引:37
作者
Eastwood, Sophie V. [1 ]
Tillin, Therese [1 ]
Sattar, Naveed [2 ]
Forouhi, Nita G. [3 ]
Hughes, Alun D. [1 ]
Chaturvedi, Nish [1 ]
机构
[1] UCL, Inst Cardiovasc Sci, London, England
[2] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland
[3] Univ Cambridge, MRC, Epidemiol Unit, Cambridge, England
基金
英国医学研究理事会;
关键词
IMPAIRED FASTING GLUCOSE; CARDIOVASCULAR-DISEASE; GLYCATED HEMOGLOBIN; ETHNIC DISPARITIES; BLOOD-PRESSURE; CARDIOMETABOLIC RISK; DIABETES MANAGEMENT; PLASMA-GLUCOSE; POPULATION; IMPACT;
D O I
10.2337/dc15-1078
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVEWe examined longitudinal associations between prediabetes and cardiovascular disease (CVD) (coronary heart disease [CHD] and stroke) in Europeans and South Asians.RESEARCH DESIGN AND METHODSThis was a U.K. cohort study of 1,336 Europeans and 1,139 South Asians, aged 40-69 years at baseline (1988-1991). Assessment included blood pressure, blood tests, anthropometry, and questionnaires. Prediabetes was determined by OGTT or HbA(1c), using either International Expert Committee (IEC) (HbA(1c) 6.0-6.5% [42-48 mmol/mol]) or American Diabetes Association (ADA) (HbA(1c) 5.7-6.5% [39-48 mmol/mol]) cut points. Incident CHD and stroke were established at 20 years from death certification, hospital admission, primary care record review, and participant report.RESULTSCompared with normoglycemic individuals, IEC-defined prediabetes was related to both CHD and CVD risk in Europeans but not South Asians (subhazard ratio for CHD 1.68 [95% CI 1.19, 2.38] vs. 1.00 [0.75, 1.33], ethnicity interaction P = 0.008, and for CVD 1.49 [1.08, 2.07] vs. 1.03 [0.78, 1.36], ethnicity interaction P = 0.04). Conversely, IEC-defined prediabetes was associated with stroke risk in South Asians but not Europeans (1.73 [1.03, 2.90] vs. 0.85 [0.44, 1.64], ethnicity interaction P = 0.11). Risks were adjusted for age, sex, smoking, total-to-HDL cholesterol ratio, waist-to-hip ratio, systolic blood pressure, and antihypertensive use. Associations were weaker for OGTT or ADA-defined prediabetes. Conversion from prediabetes to diabetes was greater in South Asians, but accounting for time to conversion did not account for these ethnic differences.CONCLUSIONSAssociations between prediabetes and CVD differed by prediabetes diagnostic criterion, type of CVD, and ethnicity, with associations being present for overall CVD in Europeans but not South Asians. Substantiation of these findings and investigation of potential explanations are required.
引用
收藏
页码:2325 / 2332
页数:8
相关论文
共 40 条
[1]   Ethnic disparities in the association of impaired fasting glucose with the 10-year cumulative incidence of type 2 diabetes [J].
Admiraal, W. M. ;
Holleman, F. ;
Snijder, M. B. ;
Peters, R. J. G. ;
Brewster, L. M. ;
Hoekstra, J. B. L. ;
Stronks, K. ;
van Valkengoed, I. G. M. .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2014, 103 (01) :127-132
[2]  
Amer Diabet Assoc, 2011, DIABETES CARE, V34, pS11, DOI [10.2337/dc10-S062, 10.2337/dc14-S081, 10.2337/dc11-S011, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc10-S011, 10.2337/dc12-s011]
[3]  
BAECKE JAH, 1982, AM J CLIN NUTR, V36, P936
[4]  
Balion CM, 2007, CLIN CHEM LAB MED, V45, P1180, DOI 10.1515/CCLM.2007.250
[5]   South Asians have adverse cerebrovascular haemodynamics, despite equivalent blood pressure, compared with Europeans. This is due to their greater hyperglycaemia [J].
Bathula, Rajaram ;
Hughes, Alun D. ;
Panerai, Ronney B. ;
Potter, John F. ;
Thom, Simon A. McG ;
Tillin, Therese ;
Shore, Angela C. ;
Hale, Rachel ;
Chambers, John ;
Kooner, Jaspal ;
Chaturvedi, Nish .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2011, 40 (06) :1490-1498
[6]  
Chapman N, 2011, ETHNIC DIS, V21, P150
[7]   Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population:: the Hoorn Study [J].
de Vegt, F ;
Dekker, JM ;
Ruhé, HG ;
Stehouwer, CDA ;
Nijpels, G ;
Bouter, LM ;
Heine, RJ .
DIABETOLOGIA, 1999, 42 (08) :926-931
[8]   Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease [J].
Di Angelantonio, Emanuele ;
Gao, Pei ;
Khan, Hassan ;
Butterworth, Adam S. ;
Wormser, David ;
Kaptoge, Stephen ;
Seshasai, Sreenivasa Rao Kondapally ;
Thompson, Alex ;
Sarwar, Nadeem ;
Willeit, Peter ;
Ridker, Paul M. ;
Barr, Elizabeth L. M. ;
Khaw, Kay-Tee ;
Psaty, Bruce M. ;
Brenner, Hermann ;
Balkau, Beverley ;
Dekker, Jacqueline M. ;
Lawlor, Debbie A. ;
Daimon, Makoto ;
Willeit, Johann ;
Njolstad, Inger ;
Nissinen, Aulikki ;
Brunner, Eric J. ;
Kuller, Lewis H. ;
Price, Jackie F. ;
Sundstrom, Johan ;
Knuiman, Matthew W. ;
Feskens, Edith J. M. ;
Verschuren, W. M. M. ;
Wald, Nicholas ;
Bakker, Stephan J. L. ;
Whincup, Peter H. ;
Ford, Ian ;
Goldbourt, Uri ;
Gomez-de-la-Camara, Agustin ;
Gallacher, John ;
Simons, Leon A. ;
Rosengren, Annika ;
Sutherland, Susan E. ;
Bjorkelund, Cecilia ;
Blazer, Dan G. ;
Wassertheil-Smoller, Sylvia ;
Onat, Altan ;
Ibanez, Alejandro Marin ;
Casiglia, Edoardo ;
Jukema, J. Wouter ;
Simpson, Lara M. ;
Giampaoli, Simona ;
Nordestgaard, Borge G. ;
Selmer, Randi .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2014, 311 (12) :1225-1233
[9]   Association of A1C with cardiovascular disease and metabolic syndrome in Asian Indians with normal glucose tolerance [J].
Dilley, James ;
Ganesan, Anbazhagan ;
Deepa, Raj ;
Deepa, Mohan ;
Sharada, Gopalakrishnan ;
Williams, O. Dale ;
Mohan, Viswanathan .
DIABETES CARE, 2007, 30 (06) :1527-1532
[10]   Thigh Fat and Muscle each Contribute to Excess Cardiometabolic Risk in South Asians, Independent of Visceral Adipose Tissue [J].
Eastwood, Sophie V. ;
Tillin, Therese ;
Wright, Andrew ;
Mayet, Jamil ;
Godsland, Ian ;
Forouhi, Nita G. ;
Whincup, Peter ;
Hughes, Alun D. ;
Chaturvedi, Nishi .
OBESITY, 2014, 22 (09) :2071-2079