Phthalate exposure increases subclinical atherosclerosis in young population

被引：47

作者：

Su, Ta-Chen ^{[1
,2
,3
]}

Hwang, Jing-Shiang ^{[4
]}

Torng, Pao-Ling ^{[5
]}

Wu, Charlene ^{[3
]}

Lin, Chien-Yu ^{[6
,7
]}

Sung, Fung-Chang ^{[8
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Environm & Occupat Med, Taipei 10002, Taiwan

[2] Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan

[3] Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Taipei 10002, Taiwan

[4] Acad Sinica, Inst Stat Sci, Taipei, Taiwan

[5] Natl Taiwan Univ Hosp, Hsin Chu Branch, Dept Obstet & Gynecol, Taipei, Taiwan

[6] Eu Chu Kong Hosp, Dept Internal Med, New Taipei 237, Taiwan

[7] Fu Jen Catholic Univ, Sch Med, New Taipei 242, Taiwan

[8] China Med Univ, Coll Publ Hlth, Dept Hlth Serv Adm, Taichung 404, Taiwan

来源：

ENVIRONMENTAL POLLUTION | 2019年 / 250卷

关键词：

Urinary phthalate metabolites; Mono-2-ethylhexyl phthalate; Mono-n-butyl phthalate; Carotid intima-media thickness; INTIMA-MEDIA THICKNESS; NATIONAL-HEALTH; CAROTID ATHEROSCLEROSIS; INSULIN-RESISTANCE; BLOOD-PRESSURE; BISPHENOL-A; ASSOCIATION; ADOLESCENTS; METABOLITES; MICROPARTICLES;

D O I：

10.1016/j.envpol.2019.04.006

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The link between phthalate exposure and the risk of subclinical atherosclerosis in young population remains unclear. This study investigated the association between phthalate exposure and subclinical atherosclerosis, in terms of carotid intima-media thickness (CIMT), in young population. From a nationwide mass urine screening for renal health, conducted in 1992-2000 among school children 6-18 years of age in Taiwan, we recruited 789 subjects to participate in the cardiovascular health examination in 2006-2008. Among them, 787 received measurements of 7 urinary phthalate metabolites and CIMT. Results showed both mean and maximal values of CIMT at all segments of carotid arteries significantly increased with the urinary mono-2-ethylhexyl phthalate (MEHP), Sigma di-(2-ethylhexyl) phthalate (DEHP), and mono-n-butyl phthalate (MnBP) in a dose-response relationship after adjustment for multiple linear regression models. Multivariate logistic regression analysis showed that higher quartiles of urinary concentrations of MEHP, Sigma DEHP, and MnBP were associated with a higher risk of thicker CIMT. Compared to subjects with the lowest quartile (Q1) of urinary MEHP, the adjusted odds ratios (95% confidence interval) for thicker CIMT among subjects with higher urinary MEHP were 2.13 (1.18-3.84) at Q2, 4.02 (2.26-7.15) at Q3 and 7.39 (4.16-13.12) at the highest Q4. In conclusion, urinary phthalate metabolites of MEHP, Sigma DEHP, and MnBP are strongly associated with CIMT in adolescents and young adults in Taiwan. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：586 / 593

页数：8

共 30 条

[1] The association between asthma and allergic symptoms in children and phthalates in house dust:: A nested case-control study [J].

Bornehag, CG ;

Sundell, J ;

Weschler, CJ ;

Sigsgaard, T ;

Lundgren, B ;

Hasselgren, M ;

Hägerhed-Engman, L .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2004, 112 (14) :1393-1397

[2] Mono-2-ethylhexyl phthalate associated with insulin resistance and lower testosterone levels in a young population [J].

Chen, Szu-Ying ;

Hwang, Jing-Shiang ;

Sung, Fung-Chang ;

Lin, Chien-Yu ;

Hsieh, Chia-Jung ;

Chen, Pau-Chung ;

Su, Ta-Chen .

ENVIRONMENTAL POLLUTION, 2017, 225 :112-117

[3] Phthalates in food and medical devices. [J].

Chou K. ;

Wright R.O. .

Journal of Medical Toxicology, 2006, 2 (3) :126-135

[4]

Clark K, 2003, HANDB ENVIRON CHEM, V3, P227

[5] Endothelial function and dysfunction - Testing and clinical relevance [J].

Deanfield, John E. ;

Halcox, Julian P. ;

Rabelink, Ton J. .

CIRCULATION, 2007, 115 (10) :1285-1295

[6] Semivolatile Organic Compounds in Homes: Strategies for Efficient and Systematic Exposure Measurement Based on Empirical and Theoretical Factors [J].

Dodson, Robin E. ;

Camann, David E. ;

Morello-Frosch, Rachel ;

Brody, Julia G. ;

Rudel, Ruthann A. .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2015, 49 (01) :113-122

[7] Phthalates: Toxicology and exposure [J].

Heudorf, Ursel ;

Mersch-Sundermann, Volker ;

Angerer, Juergen .

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2007, 210 (05) :623-634

[8] The role of exposure to phthalates from polyvinyl chloride products in the development of asthma and allergies: A systematic review and meta-analysis [J].

Jaakkola, Jouni J. K. ;

Knight, Trudy L. .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2008, 116 (07) :845-853

[9] Plastics and cardiovascular health: phthalates may disrupt heart rate variability and cardiovascular reactivity [J].

Jaimes, Rafael, III ;

Swiercz, Adam ;

Sherman, Meredith ;

Muselimyan, Narine ;

Marvar, Paul J. ;

Posnack, Nikki Gillum .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2017, 313 (05) :H1044-H1053

[10] Urinary Phthalate Metabolite Concentrations and Diabetes among Women in the National Health and Nutrition Examination Survey (NHANES) 2001-2008 [J].

James-Todd, Tamarra ;

Stahlhut, Richard ;

Meeker, John D. ;

Powell, Sheena-Gail ;

Hauser, Russ ;

Huang, Tianyi ;

Rich-Edwards, Janet .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2012, 120 (09) :1307-1313

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