Tiagabine, a γ-amino-butyric acid transporter inhibitor impairs spatial learning of rats in the Morris water-maze

gamma-Amino-butyric acid (GABA) is cleaved from the synaptic cleft by uptake via specific transporters. Inhibition of such transporters increases the effectiveness of physiologically released GABA. Increased GABAergic neurotransmission has ail impact on learning and memory. Therefore, effects of tiagabine, a GABA-transporter inhibitor, were investigated on spatial orientation in the Mori-is water-maze. Rats were given four training trials per day for 4 days and a probe trial without platform on the 5th day. Compared to saline treated rats, rats treated daily with 20 mg/kg tiagabine showed impaired learning during the acquisition trials. Retrieval was impaired in rats treated only at the probe trial with tiagabine. These results further elucidate the role of GABA in learning and memory. (C) 2002 Elsevier Science B.V. All rights reserved.