Total synthesis of naturally occurring cephalosporolides E/F

被引：21
|
作者：
Kona, Chandrababu Naidu [1 ]
Ramana, C. V. [1 ]
机构：
[1] CSIR, Div Organ Chem, Natl Chem Lab, Pune 411008, Maharashtra, India
来源：
TETRAHEDRON | 2014年 / 70卷 / 23期
关键词：
Cephalosporolide; Epoxide-alkyne coupling; Gold catalysis; Alkynetetrol; Spiroketalization; MARINE-DERIVED FUNGUS; HIGHLY EFFICIENT ACCESS; MEDIATED CYCLOISOMERIZATION; SPIROKETALS; ALKYNES; LACTONES; ALCOHOLS; CYCLIZATIONS; HETEROCYCLES; PRODUCTS;
D O I：
10.1016/j.tet.2014.04.026
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A modular total synthesis of cephalosporolides E/F featuring sequential epoxide-alkyne coupling and subsequent highly regioselective gold catalyzed alkynolcycloisomerizatio of the resulting alkynetetrol to construct the central spiroketal core has been documented. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3653 / 3656
页数：4
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