Epigenetic Mechanisms in Canine Cancer

被引：12

作者：

Xavier, Pedro Luiz Porfirio ^{[1
]}

Mueller, Susanne ^{[2
,3
]}

Fukumasu, Heidge ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, Lab Comparat & Translat Oncol LOCT, Pirassununga, Brazil

[2] Goethe Univ Frankfurt, Struct Genom Consortium, Buchmann Inst Mol Life Sci, Frankfurt, Germany

[3] Goethe Univ Frankfurt, Inst Pharmaceut Chem, Buchmann Inst Mol Life Sci, Frankfurt, Germany

来源：

FRONTIERS IN ONCOLOGY | 2020年 / 10卷

基金：

巴西圣保罗研究基金会; 加拿大创新基金会;

关键词：

comparative oncology; epigenetics; DNA methylation; histone modifications; canine cancer; non-coding RNAs; HISTONE DEACETYLASE INHIBITOR; LONG NONCODING RNA; BCR-ABL TRANSLOCATION; HUMAN BREAST-CANCER; DNA METHYLATION; PET DOGS; MICRORNA EXPRESSION; GENE-EXPRESSION; CPG ISLAND; DOWN-REGULATION;

D O I：

10.3389/fonc.2020.591843

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A plethora of data has highlighted the role of epigenetics in the development of cancer. Initiation and progression of different cancer types are associated with a variety of changes of epigenetic mechanisms, including aberrant DNA methylation, histone modifications, and miRNA expression. At the same time, advances in the available epigenetic tools allow to investigate and reverse these epigenetic changes and form the basis for the development of anticancer drugs in human oncology. Although human and canine cancer shares several common features, only recently that studies emerged investigating the epigenetic landscape in canine cancer and applying epigenetic modulators to canine cancer. This review focuses on the existing studies involving epigenetic changes in different types of canine cancer and the use of small-molecule inhibitors in canine cancer cells.

引用

页数：17

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