Diagnostic value of 18F-FDG PET/CT in patients with TENIS syndrome: correlation with thyroglobulin levels

被引:26
作者
Ozdemir, Elif [1 ]
Poyraz, Nilufer Yildirim [1 ]
Polat, Sefika Burcak [2 ]
Turkolmez, Seyda [1 ]
Ersoy, Reyhan [2 ]
Cakir, Bekir [2 ]
机构
[1] Ataturk Training & Res Hosp, Dept Nucl Med, TR-06530 Ankara, Turkey
[2] Ataturk Training & Res Hosp, Dept Endocrinol & Metab, TR-06530 Ankara, Turkey
关键词
F-18-FDG-PET/CT; Thyroglobulin; Differentiated thyroid cancer; Radioiodine imaging; DIFFERENTIATED THYROID-CARCINOMA; POSITRON-EMISSION-TOMOGRAPHY; WHOLE-BODY SCAN; ELEVATED THYROGLOBULIN; SERUM THYROGLOBULIN; CANCER PATIENTS; F-18-FDG PET/CT; FDG-PET/CT; FOLLOW-UP; RECURRENT;
D O I
10.1007/s12149-013-0801-x
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The aim of the study was to disclose the place of F-18-FDG PET/CT to predict recurrent disease in patients with differentiated thyroid cancer (DTC), negative radioiodine whole-body scan (WBS) and high serum thyroglobulin (Tg). Seventy-one patients who underwent total thyroidectomy followed by radioactive iodine ablation and had negative radioiodine WBS but elevated Tg levels underwent PET/CT. They were followed up for 6-50 months (median 23) for the occurence of recurrent disease as detected by either clinical findings, other imaging modalities or histopathological examination. The place of PET/CT findings at baseline to predict the presence of recurrent disease was evaluated. Correlation between PET/CT findings and Tg levels was examined and a threshold for Tg level above which the predictive value of PET/CT was highest was determined. PET/CT was positive for recurrent disease in 38 (53.5 %) patients. The sensitivity, specificity, PPV, NPV and diagnostic accuracy of PET/CT to predict the occurence of recurrent disease at follow-up were 68.8, 78.3, 86.8, 54.5 and 71.9 %, respectively. The sensitivity, accuracy and PPV of PET/CT increased with increasing Tg levels. The highest diagnostic accuracy of PET/CT, with a sensitivity of 76.2 % and a specificity of 100 % to detect recurrent disease appeared to be at a Tg level greater than 29 ng/mL. Our findings suggest that F-18-FDG-PET/CT is a valuable tool to predict the occurence of recurrent disease in patients with DTC, negative WBS and elevated Tg levels. PET/CT positivity has been shown to be strongly and positively correlated with Tg levels in this patient subset.
引用
收藏
页码:241 / 247
页数:7
相关论文
共 32 条
[1]  
Akkas BE, 2013, THYROID, DOI [10.1089/thy.2012.0195, DOI 10.1089/THY.2012.0195]
[2]   THE COMPARATIVE VALUE OF SERUM THYROGLOBULIN MEASUREMENTS AND I-131 TOTAL-BODY SCANS IN THE FOLLOW-UP-STUDY OF PATIENTS WITH TREATED DIFFERENTIATED THYROID-CANCER [J].
ASHCRAFT, MW ;
VANHERLE, AJ .
AMERICAN JOURNAL OF MEDICINE, 1981, 71 (05) :806-814
[3]   Can 18F-FDG-PET/CT be generally recommended in patients with differentiated thyroid carcinoma and elevated thyroglobulin levels but negative I-131 whole body scan? [J].
Bannas, Peter ;
Derlin, Thorsten ;
Groth, Michael ;
Apostolova, Ivayla ;
Adam, Gerhard ;
Mester, Janos ;
Klutmann, Susanne .
ANNALS OF NUCLEAR MEDICINE, 2012, 26 (01) :77-85
[4]   Role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in patients affected by differentiated thyroid carcinoma, high thyroglobulin level, and negative 131I scan: review of the literature [J].
Bertagna, Francesco ;
Biasiotto, Giorgio ;
Orlando, Emanuela ;
Bosio, Giovanni ;
Giubbini, Raffaele .
JAPANESE JOURNAL OF RADIOLOGY, 2010, 28 (09) :629-636
[5]   F-18 FDG-PET/CT Evaluation of Patients With Differentiated Thyroid Cancer With Negative I-131 Total Body Scan and High Thyroglobulin Level [J].
Bertagna, Francesco ;
Bosio, Giovanni ;
Biasiotto, Giorgio ;
Rodella, Carlo ;
Puta, Erinda ;
Gabanelli, Sara ;
Lucchini, Silvia ;
Merli, Giuseppe ;
Savelli, Giordano ;
Giubbini, Raffaele ;
Rosenbaum, Joshua ;
Alavi, Abass .
CLINICAL NUCLEAR MEDICINE, 2009, 34 (11) :756-761
[6]   Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer [J].
Cooper, David S. ;
Doherty, Gerard M. ;
Haugen, Bryan R. ;
Kloos, Richard T. ;
Lee, Stephanie L. ;
Mandel, Susan J. ;
Mazzaferri, Ernest L. ;
McIver, Bryan ;
Pacini, Furio ;
Schlumberger, Martin ;
Sherman, Steven I. ;
Steward, David L. ;
Tuttle, R. Michael .
THYROID, 2009, 19 (11) :1167-1214
[7]   Influence of TSH on uptake of [18F]fluorodeoxyglucose in human thyroid cells in vitro [J].
Deichen, JT ;
Schmidt, C ;
Prante, O ;
Maschauer, S ;
Papadopoulos, T ;
Kuwert, T .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2004, 31 (04) :507-512
[8]   Value of 18F-FDG-PET/PET-CT in differentiated thyroid carcinoma with radioiodine-negative whole-body scan: a meta-analysis [J].
Dong, Meng-Jie ;
Liu, Zhen-Feng ;
Zhao, Kui ;
Ruan, Ling-Xiang ;
Wang, Guo-Lin ;
Yang, Shu-Ye ;
Sun, Fang ;
Luo, Xu-Guang .
NUCLEAR MEDICINE COMMUNICATIONS, 2009, 30 (08) :639-650
[9]  
Feine U, 1996, J NUCL MED, V37, P1468
[10]   THYROTROPIN STIMULATES GLUCOSE-TRANSPORT IN CULTURED RAT-THYROID CELLS [J].
FILETTI, S ;
DAMANTE, G ;
FOTI, D .
ENDOCRINOLOGY, 1987, 120 (06) :2576-2581