The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases

被引：89
作者：
Acker, Till
Fandrey, Joachim
Acker, Helmut
机构：
[1] Univ Duisburg Essen, Inst Physiol, D-45147 Essen, Germany
[2] Univ Frankfurt Klinikum, Neurol Inst, Edinger Inst, D-60528 Frankfurt, Germany
来源：
CARDIOVASCULAR RESEARCH | 2006年 / 71卷 / 02期
关键词：
ROS; HIF; PHD; cytochromes; ion channels; oxygen-sensing;
D O I：
10.1016/j.cardiores.2006.04.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Current concepts of cellular oxygen-sensing include an isoform of the neutrophil NADPH oxidase, different electron carrier units of the mitochondrial electron transport chain (ETC), heme oxygenase-2 (HO-2), and a subfamily of 2-oxoglutarate dependent dioxygenases termed HIF (hypoxia inducible factor) prolyl hydroxylases (PHDs) and HIF asparagyl hydroxylase FIH-1 (factor-inhibiting HIF). Different oxygen sensitivities, cell-specific distribution and subcellular localization of specific oxygen-sensing cascades involving reactive oxygen species (ROS) as second messengers may help to tailor various adaptive responses according to differences in tissue oxygen availability. Herein, we propose an integrated model for these various oxygen-sensing mechanisms that very efficiently regulate HIF-alpha activity and plasma membrane potassium-channel (PMPC) conductivity. (c) 2006 European Society of Cardiology. Published by Elsevier B.V All rights reserved.
引用
收藏
页码：195 / 207
页数：13
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