Design and synthesis of novel quinic acid derivatives: in vitro cytotoxicity and anticancer effect on glioblastoma

被引：14

作者：

Murugesan, Akshaya ^{[1
,2
,3
]}

Holmstedt, Suvi ^{[4
]}

Brown, Kenna C. ^{[1
]}

Koivuporras, Alisa ^{[4
]}

Macedo, Ana S. ^{[5
]}

Nguyen, Nga ^{[1
]}

Fonte, Pedro ^{[6
,7
,8
]}

Rijo, Patricia ^{[9
,10
]}

Yli-Harja, Olli ^{[11
,12
]}

Candeias, Nuno R. ^{[4
,13
]}

Kandhavelu, Meenakshisundaram ^{[1
,2
,3
]}

机构：

[1] Tampere Univ, Fac Med & Hlth Technol, Mol Signaling Lab, Tampere, Finland

[2] Tampere Univ Hosp, BioMeditech & Tays Canc Ctr, POB 553, Tampere 33101, Finland

[3] Lady Doak Coll, Dept Biotechnol, Madurai 625002, Tamil Nadu, India

[4] Tampere Univ, Fac Engn & Nat Sci, Tampere 33101, Finland

[5] Univ Aveiro, Dept Chem, LAQV REQUIMTE, P-3810193 Aveiro, Portugal

[6] Univ Algarve, Ctr Marine Sci CCMAR, Gambelas Campus, P-8005139 Faro, Portugal

[7] Univ Algarve, Fac Sci & Technol, Dept Chem & Pharm, Gambelas Campus, P-8005139 Faro, Portugal

[8] Univ Lisbon, Inst Super Tecn, Dept Bioengn, iBB Inst Bioengn & Biosci, P-1049001 Lisbon, Portugal

[9] Univ Lusofona Humanidades & Tecnol, Res Ctr Biosci & Hlth Technol CBIOS, P-1749024 Lisbon, Portugal

[10] Univ Lisbon, Fac Farm, Inst Invest Med iMed ULisboa, P-1649003 Lisbon, Portugal

[11] Tampere Univ, Fac Med & Hlth Technol, Computat Syst Biol Grp, POB 553, Tampere 33101, Finland

[12] Inst Syst Biol, 1441N 34th St, Seattle, WA 98103 USA

[13] Univ Lusofona Lisboa, Escola Ciencias & Tecnol Saude, P-1749024 Lisbon, Portugal

来源：

FUTURE MEDICINAL CHEMISTRY | 2020年 / 12卷 / 21期

基金：

芬兰科学院;

关键词：

chemotherapeutic drugs; cytotoxicity; glioblastoma; nanoparticle; PLGA; quinic acid; NANOPARTICLES; TEMOZOLOMIDE; DELIVERY; CHEMOTHERAPY; INHIBITORS; DEPENDS; KINASE; CELLS;

D O I：

10.4155/fmc-2020-0194

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aim: Quinic acid (QA) is a cyclic polyol exhibiting anticancer properties on several cancers. However, potential role of QA-derivatives against glioblastoma is not well established. Methodology & results: Sixteen novel QA-derivatives and QA-16 encapsulated poly (lactic-co-glycolic acid) nanoparticles (QA-16-NPs) were screened for their anti-glioblastoma effect using standard cell and molecular biology methods. Presence of a tertiary hydroxy and silylether groups in the lead compound were identified for the antitumor activity. QA-16 have 90% inhibition with the IC50 of 10.66 mu M and 28.22 mu M for LN229 and SNB19, respectively. The induction of apoptosis is faster with the increased fold change of caspase 3/7 and reactive oxygen species. Conclusion: QA-16 and QA-16-NPs shows similar cytotoxicity effect, providing opportunity to use QA-16 as a potential chemotherapeutic agent.

引用

页码：1891 / 1910

页数：20

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