A Novel Cardiotoxic Mechanism for a Pervasive Global Pollutant

被引：124
作者：
Brette, Fabien [1 ,5 ]
Shiels, Holly A. [2 ,5 ]
Galli, Gina L. J. [2 ]
Cros, Caroline [1 ,5 ]
Incardona, John P. [3 ]
Scholz, Nathaniel L. [3 ]
Block, Barbara A. [1 ,4 ]
机构：
[1] Stanford Univ, Hopkins Marine Stn, Dept Biol, Pacific Grove, CA 93950 USA
[2] Univ Manchester, Fac Biol Med & Hlth, Div Cardiovasc Sci, Manchester M13 9NT, Lancs, England
[3] NOAA, Northwest Fisheries Sci Ctr, Seattle, WA 98112 USA
[4] Stanford Univ, Hopkins Marine Stn, Tuna Res & Conservat Ctr, Pacific Grove, CA 93950 USA
[5] Univ Bordeaux, INSERM U1045, LIRYC Inst Rythmol & Modelisat Cardiaque, Campus Xavier Arnozan PTIB, F-33600 Pessac, France
来源：
SCIENTIFIC REPORTS | 2017年 / 7卷
关键词：
POLYCYCLIC AROMATIC-HYDROCARBONS; WEATHERED CRUDE-OIL; FISH EMBRYOS; DEVELOPMENTAL TOXICITY; CARDIAC-ARRHYTHMIA; ZEBRAFISH; EXPOSURE; SENSITIVITY; CHANNELS; ABNORMALITIES;
D O I：
10.1038/srep41476
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The Deepwater Horizon disaster drew global attention to the toxicity of crude oil and the potential for adverse health effects amongst marine life and spill responders in the northern Gulf of Mexico. The blowout released complex mixtures of polycyclic aromatic hydrocarbons (PAHs) into critical pelagic spawning habitats for tunas, billfishes, and other ecologically important top predators. Crude oil disrupts cardiac function and has been associated with heart malformations in developing fish. However, the precise identity of cardiotoxic PAHs, and the mechanisms underlying contractile dysfunction are not known. Here we show that phenanthrene, a PAH with a benzene 3-ring structure, is the key moiety disrupting the physiology of heart muscle cells. Phenanthrene is a ubiquitous pollutant in water and air, and the cellular targets for this compound are highly conserved across vertebrates. Our findings therefore suggest that phenanthrene may be a major worldwide cause of vertebrate cardiac dysfunction.
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页数：9
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