Severe Hypophosphatemic Osteomalacia with Fanconi Syndrome, Renal Tubular Acidosis, Vitamin D Deficiency and Primary Biliary Cirrhosis

被引：10

作者：

Bando, Hironori ^{[1
]}

Hashimoto, Naoko ^{[1
]}

Hirota, Yushi ^{[1
]}

Sakaguchi, Kazuhiko ^{[1
]}

Hisa, Itoko ^{[1
]}

Inoue, Yoshifumi ^{[1
]}

Imanishi, Yasuo ^{[2
]}

Seino, Susumu ^{[1
]}

Kaji, Hiroshi ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Endocrinol Diabet & Metab, Kobe, Hyogo 657, Japan

[2] Osaka City Univ, Grad Sch Med, Dept Metab Endocrinol & Mol Med, Osaka 558, Japan

来源：

INTERNAL MEDICINE | 2009年 / 48卷 / 05期

关键词：

osteomalacia; vitamin D; fanconi syndrome; renal tubular acidosis; primary biliary cirrhosis; BONE-DISEASE; FGF23;

D O I：

10.2169/internalmedicine.48.1644

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 49-year-old woman was admitted to our hospital for back pain with marked thoracic and extremity deformities leading to bed-rest for three years. She was diagnosed with hypophosphatemic osteomalacia based on her symptoms, X-ray and bone scintigram, high serum alkaline phosphatase level, and low serum levels of both phosphorus and 1,25 dihydroxyvitamin D-3 with inhibition of phosphorus reabsorption. Fanconi syndrome with renal tubular acidosis, vitamin D deficiency and primary biliary cirrhosis were related to the pathogenesis of osteomalacia in this case. Several causal diseases may be concomitantly responsible for acceleration of the severity of osteomalacia in this patient.

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收藏

页码：353 / 358

页数：6

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