Immature platelets: a review of the available evidence

被引：28

作者：

Benlachgar, Naoufal ^{[1
]}

Doghmi, Kamal ^{[1
]}

Masrar, Azlarab ^{[2
]}

Mahtat, El Mehdi ^{[1
]}

Harmouche, Hicham ^{[3
]}

Mezalek, Zoubida Tazi ^{[3
]}

机构：

[1] Mil Hosp Instruct Mohamed V, Dept Clin Haematol, Rabat, Morocco

[2] Univ Mohamed V Med, Ibn Sina Hosp, Cent Lab Hematol, Rue Lamfadel Cherkaoui,BP 6527, Rabat, Morocco

[3] Univ Mohamed V Med, Ibn Sina Hosp, Internal Med Dept, Rue Lamfadel Cherkaoui,BP 6527, Rabat, Morocco

来源：

THROMBOSIS RESEARCH | 2020年 / 195卷

关键词：

Immature platelets; Immune thrombocytopenia; Reticulated platelets; Thrombocytopenia; CORONARY-ARTERY-DISEASE; RETICULATED PLATELETS; REFERENCE INTERVALS; HEMATOLOGY ANALYZER; PREDICTIVE-VALUE; THROMBOCYTOPENIC PURPURA; THROMBOPOIETIC RECOVERY; IMMUNE THROMBOCYTOPENIA; CLINICAL-SIGNIFICANCE; FRACTION MEASUREMENT;

D O I：

10.1016/j.thromres.2020.06.048

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immature platelets or reticulated platelets are newly released thrombocytes. They can be identified by their large size and high RNA cytoplasm concentration. Immature platelet fraction (IPF) represents the percentage of immature circulative platelets to the total number of platelets. The development of analytical standardization of this hematological parameter by new automated devices allowed a better exploration of its contribution in a context of thrombocytopenia. In fact, several studies had confirmed its clinical utility to differentiate immune thrombocytopenia from other causes of thrombocytopenia. IPF can also predict platelets recovery after chemotherapy and successful engraftment. In addition, immature platelets have shown utility in other diseases such as coronary artery diseases, bacterial infections and liver diseases. Despite all these advantages, immature platelet fraction can be increased in some cases of thrombocytopenia characterized by platelets hypoproduction. The aim of this review is to present the immature platelet fraction contribution in clinical practice.

引用

页码：43 / 50

页数：8

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