Highly Chemo-, Regio-, and Enantioselective Rhodium-Catalyzed Cross-Cyclotrimerization of Two Different Alkynes with Alkenes

被引：40
|
作者：
Hara, Jun [1 ]
Ishida, Mana [1 ]
Kobayashi, Masayuki [1 ]
Noguchi, Keiichi [2 ]
Tanaka, Ken [1 ,3 ]
机构：
[1] Tokyo Univ Agr & Technol, Dept Appl Chem, Grad Sch Engn, Koganei, Tokyo 1848588, Japan
[2] Tokyo Univ Agr & Technol, Instrumentat Anal Ctr, Koganei, Tokyo 1848588, Japan
[3] Japan Sci & Technol Agcy JST, ACT C, Kawaguchi, Saitama 3320012, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 11期
基金：
日本科学技术振兴机构;
关键词：
alkenes; alkynes; asymmetric catalysis; cyclotrimerization; multicomponent reactions; rhodium; REGIOSELECTIVE INTERMOLECULAR CYCLOTRIMERIZATION; 3 UNSYMMETRICAL ALKYNES; BORON TEMPORARY TETHER; LIQUID ENOL ETHERS; 2+2+2 CYCLOADDITION; ETHYL CYCLOPROPYLIDENEACETATE; TERMINAL ALKYNES; NICKEL; COMPLEXES; PYRIDINES;
D O I：
10.1002/anie.201310336
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
It has been established that a cationic rhodium(I)/(R)-tol-binap complex catalyzes the cross-cyclotrimerization of silylacetylenes, di-tert-butyl acetylenedicarboxylates, and acrylamides with excellent chemo-, regio-, and enantioselectivities. Unsymmetrical alkynoates can also be employed in place of di-tert-butyl acetylenedicarboxylate for this process, but with reduced chemoselectivity.
引用
收藏
页码：2956 / 2959
页数：4
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