Highly Chemo-, Regio-, and Enantioselective Rhodium-Catalyzed Cross-Cyclotrimerization of Two Different Alkynes with Alkenes

被引：40

作者：

Hara, Jun ^{[1
]}

Ishida, Mana ^{[1
]}

Kobayashi, Masayuki ^{[1
]}

Noguchi, Keiichi ^{[2
]}

Tanaka, Ken ^{[1
,3
]}

机构：

[1] Tokyo Univ Agr & Technol, Dept Appl Chem, Grad Sch Engn, Koganei, Tokyo 1848588, Japan

[2] Tokyo Univ Agr & Technol, Instrumentat Anal Ctr, Koganei, Tokyo 1848588, Japan

[3] Japan Sci & Technol Agcy JST, ACT C, Kawaguchi, Saitama 3320012, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 11期

基金：

日本科学技术振兴机构;

关键词：

alkenes; alkynes; asymmetric catalysis; cyclotrimerization; multicomponent reactions; rhodium; REGIOSELECTIVE INTERMOLECULAR CYCLOTRIMERIZATION; 3 UNSYMMETRICAL ALKYNES; BORON TEMPORARY TETHER; LIQUID ENOL ETHERS; 2+2+2 CYCLOADDITION; ETHYL CYCLOPROPYLIDENEACETATE; TERMINAL ALKYNES; NICKEL; COMPLEXES; PYRIDINES;

D O I：

10.1002/anie.201310336

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It has been established that a cationic rhodium(I)/(R)-tol-binap complex catalyzes the cross-cyclotrimerization of silylacetylenes, di-tert-butyl acetylenedicarboxylates, and acrylamides with excellent chemo-, regio-, and enantioselectivities. Unsymmetrical alkynoates can also be employed in place of di-tert-butyl acetylenedicarboxylate for this process, but with reduced chemoselectivity.

引用

页码：2956 / 2959

页数：4

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