Early Acquisition of Anogenital Human Papillomavirus Among Teenage Men Who Have Sex With Men

被引：58
作者：
Zou, Huachun [1 ]
Tabrizi, Sepehr N. [2 ,3 ,4 ]
Grulich, Andrew E. [5 ]
Garland, Suzanne M. [2 ,3 ,4 ]
Hocking, Jane S. [6 ]
Bradshaw, Catriona S. [1 ,7 ,8 ]
Morrow, Andrea [7 ]
Prestage, Garrett [5 ,9 ]
Cornall, Alyssa M. [3 ,4 ]
Fairley, Christopher K. [1 ,7 ,9 ]
Chen, Marcus Y. [1 ,7 ,9 ]
机构：
[1] Univ Melbourne, Sch Populat & Global Hlth, Melbourne, Vic, Australia
[2] Univ Melbourne, Dept Obstet & Gynaecol, Melbourne, Vic, Australia
[3] Royal Womens Hosp, Dept Microbiol & Infect Dis, Melbourne, Vic, Australia
[4] Murdoch Childrens Res Inst, Melbourne, Vic, Australia
[5] Univ New S Wales, Kirby Inst, Sydney, NSW, Australia
[6] Univ Melbourne, Ctr Womens Hlth Gender & Soc, Melbourne, Vic, Australia
[7] Alfred Hlth, Melbourne Sexual Hlth Ctr, Melbourne, Vic, Australia
[8] Monash Univ, Cent Clin Sch, Melbourne, Vic 3004, Australia
[9] La Trobe Univ, Australian Res Ctr Sex Hlth & Soc, Melbourne, Vic, Australia
来源：
JOURNAL OF INFECTIOUS DISEASES | 2014年 / 209卷 / 05期
基金：
英国医学研究理事会;
关键词：
human papillomavirus; HPV; men who have sex with men; vaccination; sexually transmitted infections; ANAL HUMAN-PAPILLOMAVIRUS; HPV VACCINATION PROGRAM; AGE-SPECIFIC PREVALENCE; RISK-FACTORS; MALE CIRCUMCISION; CERVICAL-CANCER; YOUNG MEN; INFECTION; AMPLIFICATION; AUSTRALIA;
D O I：
10.1093/infdis/jit626
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background. Anogenital human papillomavirus (HPV) is common among men who have sex with men (MSM) and causes anal cancer. This study examined the determinants of initial anogenital HPV infection among teenage MSM. Methods. Two hundred MSM aged 16 to 20 years were recruited via community and other sources. Men were tested for HPV DNA from the anus and penis. Results. The proportion of men with anal HPV of any type increased from 10.0% in men reporting no prior receptive anal sex to 47.3% in men reporting >= 4 receptive anal sex partners (P < .001).A similar pattern was also seen with HPV type 16 (P = .044). The proportion of men with penile HPV increased from 3.7% in men reporting no prior insertive anal sex to 14.8% in men reporting >= 4 insertive anal sex partners (P = .014). Overall, 39.0% (95% confidence interval (CI), 32.2%-46.1%) of men had at least 1 HPV type: 23.0% (95% CI, 17.4%-29.5%) had a vaccine-preventable type (6, 11, 16 or 18). Conclusions. Early and high per partner transmission of HPV occurred between men soon after their first sexual experiences. HPV vaccination needs to commence early for maximal prevention of HPV among MSM.
引用
收藏
页码：642 / 651
页数：10
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