Early Acquisition of Anogenital Human Papillomavirus Among Teenage Men Who Have Sex With Men

被引：57

作者：

Zou, Huachun ^{[1
]}

Tabrizi, Sepehr N. ^{[2
,3
,4
]}

Grulich, Andrew E. ^{[5
]}

Garland, Suzanne M. ^{[2
,3
,4
]}

Hocking, Jane S. ^{[6
]}

Bradshaw, Catriona S. ^{[1
,7
,8
]}

Morrow, Andrea ^{[7
]}

Prestage, Garrett ^{[5
,9
]}

Cornall, Alyssa M. ^{[3
,4
]}

Fairley, Christopher K. ^{[1
,7
,9
]}

Chen, Marcus Y. ^{[1
,7
,9
]}

机构：

[1] Univ Melbourne, Sch Populat & Global Hlth, Melbourne, Vic, Australia

[2] Univ Melbourne, Dept Obstet & Gynaecol, Melbourne, Vic, Australia

[3] Royal Womens Hosp, Dept Microbiol & Infect Dis, Melbourne, Vic, Australia

[4] Murdoch Childrens Res Inst, Melbourne, Vic, Australia

[5] Univ New S Wales, Kirby Inst, Sydney, NSW, Australia

[6] Univ Melbourne, Ctr Womens Hlth Gender & Soc, Melbourne, Vic, Australia

[7] Alfred Hlth, Melbourne Sexual Hlth Ctr, Melbourne, Vic, Australia

[8] Monash Univ, Cent Clin Sch, Melbourne, Vic 3004, Australia

[9] La Trobe Univ, Australian Res Ctr Sex Hlth & Soc, Melbourne, Vic, Australia

来源：

JOURNAL OF INFECTIOUS DISEASES | 2014年 / 209卷 / 05期

基金：

英国医学研究理事会;

关键词：

human papillomavirus; HPV; men who have sex with men; vaccination; sexually transmitted infections; ANAL HUMAN-PAPILLOMAVIRUS; HPV VACCINATION PROGRAM; AGE-SPECIFIC PREVALENCE; RISK-FACTORS; MALE CIRCUMCISION; CERVICAL-CANCER; YOUNG MEN; INFECTION; AMPLIFICATION; AUSTRALIA;

D O I：

10.1093/infdis/jit626

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Anogenital human papillomavirus (HPV) is common among men who have sex with men (MSM) and causes anal cancer. This study examined the determinants of initial anogenital HPV infection among teenage MSM. Methods. Two hundred MSM aged 16 to 20 years were recruited via community and other sources. Men were tested for HPV DNA from the anus and penis. Results. The proportion of men with anal HPV of any type increased from 10.0% in men reporting no prior receptive anal sex to 47.3% in men reporting >= 4 receptive anal sex partners (P < .001).A similar pattern was also seen with HPV type 16 (P = .044). The proportion of men with penile HPV increased from 3.7% in men reporting no prior insertive anal sex to 14.8% in men reporting >= 4 insertive anal sex partners (P = .014). Overall, 39.0% (95% confidence interval (CI), 32.2%-46.1%) of men had at least 1 HPV type: 23.0% (95% CI, 17.4%-29.5%) had a vaccine-preventable type (6, 11, 16 or 18). Conclusions. Early and high per partner transmission of HPV occurred between men soon after their first sexual experiences. HPV vaccination needs to commence early for maximal prevention of HPV among MSM.

引用

页码：642 / 651

页数：10

共 31 条

[1] Effect of Male Circumcision on the Prevalence of High-Risk Human Papillomavirus in Young Men: Results of a Randomized Controlled Trial Conducted in Orange Farm, South Africa
Auvert, Bertran
Sobngwi-Tambekou, Joelle
Cutler, Ewalde
Nieuwoudt, Marthi
Lissouba, Pascale
Puren, Adrian
Taljaard, Dirk
[J]. JOURNAL OF INFECTIOUS DISEASES, 2009, 199 (01) : 14 - 19
[2] Early effect of the HPV vaccination programme on cervical abnormalities in Victoria, Australia: an ecological study
Brotherton, Julia M. L.
Fridman, Masha
May, Cathryn L.
Chappell, Genevieve
Saville, A. Marion
Gertig, Dorota M.
[J]. LANCET, 2011, 377 (9783) : 2085 - 2092
[3] Male circumcision, penile human papillomavirus infection, and cervical cancer in female partners.
Castellsague, X
Bosch, FX
Munoz, N
Meijer, CJLM
Shah, KV
de Sanjose, S
Eluf-Neto, J
Ngelangel, CA
Chichareon, S
Smith, JS
Herrero, R
Moreno, V
Franceschi, S
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (15) : 1105 - 1112
[4] Age-specific prevalence of anal human papillomavirus infection in HIV-Negative sexually active men who have sex with men: The EXPLORE study
Chin-Hong, PV
Vittinghoff, E
Cranston, RD
Buchbinder, S
Cohen, D
Colfax, G
Da Costa, M
Darragh, T
Hess, E
Judson, F
Koblin, B
Madison, M
Da Costa, M
[J]. JOURNAL OF INFECTIOUS DISEASES, 2004, 190 (12) : 2070 - 2076
[5] Prevalence, Clearance, and Incidence of Anal Human Papillomavirus Infection in HIV-Infected Men: The HIPVIRG Cohort Study
de Pokomandy, Alexandra
Rouleau, Danielle
Ghattas, George
Vezina, Sylvie
Cote, Pierre
Macleod, John
Allaire, Guy
Franco, Eduardo L.
Coutlee, Francois
[J]. JOURNAL OF INFECTIOUS DISEASES, 2009, 199 (07) : 965 - 973
[6] Quadrivalent human papillomavirus vaccination and trends in genital warts in Australia: analysis of national sentinel surveillance data
Donovan, Basil
Franklin, Neil
Guy, Rebecca
Grulich, Andrew E.
Regan, David G.
Ali, Hammad
Wand, Handan
Fairley, Christopher K.
[J]. LANCET INFECTIOUS DISEASES, 2011, 11 (01) : 39 - 44
[7] Model for assessing human papillomavirus vaccination strategies
Elbasha, Elamin H.
Dasbach, Erik J.
Insinga, Ralph P.
[J]. EMERGING INFECTIOUS DISEASES, 2007, 13 (01) : 28 - 41
[8] Rapid decline in presentations of genital warts after the implementation of a national quadrivalent human papillomavirus vaccination programme for young women
Fairley, C. K.
Hocking, J. S.
Gurrin, L. C.
Chen, M. Y.
Donovan, B.
Bradshaw, C. S.
[J]. SEXUALLY TRANSMITTED INFECTIONS, 2009, 85 (07) : 499 - 502
[9] Efficacy of Quadrivalent HPV Vaccine against HPV Infection and Disease in Males
Giuliano, Anna R.
Palefsky, Joel M.
Goldstone, Stephen
Moreira, Edson D., Jr.
Penny, Mary E.
Aranda, Carlos
Vardas, Eftyhia
Moi, Harald
Jessen, Heiko
Hillman, Richard
Chang, Yen-Hwa
Ferris, Daron
Rouleau, Danielle
Bryan, Janine
Marshall, J. Brooke
Vuocolo, Scott
Barr, Eliav
Radley, David
Haupt, Richard M.
Guris, Dalya
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (05) : 401 - 411
[10] High Rates of Incident and Prevalent Anal Human Papillomavirus Infection Among Young Men Who Have Sex With Men
Glick, Sara Nelson
Feng, Qinghua
Popov, Viorica
Koutsky, Laura A.
Golden, Matthew R.
[J]. JOURNAL OF INFECTIOUS DISEASES, 2014, 209 (03) : 369 - 376

← 1 2 3 4 →