miRNAs and Biomarkers in Testicular Germ Cell Tumors: An Update

被引：21
作者：
De Martino, Marco [1 ,2 ]
Chieffi, Paolo [3 ]
Esposito, Francesco [1 ]
机构：
[1] Univ Napoli Federico II, Dipartimento Med Mol & Biotecnol Med, Ist Endocrinol & Oncol Sperimentale, CNR, I-80131 Naples, Italy
[2] Univ Campania L Vanvitelli, Dipartimento Med Precisione, I-80138 Naples, Italy
[3] Univ Campania L Vanvitelli, Dipartimento Psicol, I-81100 Caserta, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 03期
关键词：
testicular germ cell tumors; microRNA; biomarker; ESTROGEN-RECEPTOR-BETA; HUMAN GASTRIC-CANCER; AURORA-B EXPRESSION; THERAPEUTIC TARGETS; MICRORNAS; MIR-373; PROTEIN; PROLIFERATION; SUPPRESSOR; BIOLOGY;
D O I：
10.3390/ijms22031380
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Testicular germ cell tumors (TGCTs) are the leading form of solid cancer and death affecting males between the ages of 20 and 40. Today, their surgical resection and chemotherapy are the treatments of first choice, even if sometimes this is not enough to save the lives of patients with TGCT. As seen for several tumors, the deregulation of microRNAs (miRNAs) is also a key feature in TGCTs. miRNAs are small molecules of RNA with biological activity that are released into biological fluids by testicular cancer cells. Their presence, therefore, can be detected and monitored by considering miRNAs as diagnostic and prognostic markers for TGCTs. The purpose of this review is to collect all the studies executed on miRNAs that have a potential role as biomarkers for testicular tumors.
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页码：1 / 11
页数：11
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