Animal models of cavitation in pulmonary tuberculosis

被引：59
作者：
Helke, Kris L.
Mankowski, Joseph L.
Manabe, Yukari C.
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21231 USA
[2] Johns Hopkins Univ, Sch Med, Dept Comparat Med, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
[4] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA
[5] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA
来源：
TUBERCULOSIS | 2006年 / 86卷 / 05期
关键词：
review; cavitation; tuberculosis; animal models; rabbit; guinea pig; monkey;
D O I：
10.1016/j.tube.2005.09.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Transmission of tuberculosis occurs with the highest frequency from patients with extensive, cavitary, pulmonary disease and positive sputum smear microscopy. In animal models of tuberculosis, the development of caseous necrosis is an important prerequisite for the formation of cavities although the immunological triggers for liquefaction are unknown. We review the relative merits and the information gleaned from the available animal models of pulmonary cavitation. Understanding the host-pathogen interaction important to the formation of cavities may Lead to new strategies to prevent cavitation and thereby, block transmission. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：337 / 348
页数：12
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