More intensive CMV-infection in chronic heart failure patients contributes to higher T-lymphocyte differentiation degree

被引：14

作者：

Antonio Moro-Garcia, Marco ^{[1
]}

Lopez-Iglesias, Fernando ^{[2
]}

Marcos-Fernandez, Raquel ^{[1
]}

Bueno-Garcia, Eva ^{[1
]}

Diaz-Molina, Beatriz ^{[2
]}

Luis Lambert, Jose ^{[2
]}

Manuel Suarez-Garcia, Francisco ^{[3
]}

Moris de la Tassa, Cesar ^{[2
]}

Alonso-Arias, Rebeca ^{[1
]}

机构：

[1] Hosp Univ Cent Asturias, Immunol Dept, Oviedo 33011, Spain

[2] Hosp Univ Cent Asturias, Serv Cardiol, Secc Hemodinam & Cardiol Intervencionista, Oviedo, Spain

[3] Hosp Cruz Roja, Geriatr Dept, Gijon, Spain

来源：

CLINICAL IMMUNOLOGY | 2018年 / 192卷

关键词：

Aging; Lymphocytes; Inflammation; Antigens; CMV; Heart failure; CYTOMEGALOVIRUS-INFECTION; IMMUNE-SYSTEM; CHRONIC INFLAMMATION; CELLS; MORTALITY; DISEASE; IMMUNOSENESCENCE; SUBPOPULATIONS; REACTIVATION; STRESS;

D O I：

10.1016/j.clim.2018.03.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunosenescence in chronic heart failure (CHF) is characterized by a high frequency of differentiated T-lymphocytes, contributing to an inflammatory status and a deficient ability to generate immunocompetent responses. CMV is the best known inducer of T-lymphocyte differentiation, and is associated with the phenomenon of immunosenescence. In this study, we included 58 elderly chronic heart failure patients (ECHF), 60 healthy elderly controls (HEC), 40 young chronic heart failure patients (YCHF) and 40 healthy young controls (HYC). High differentiation of CD8 + T-lymphocytes was found in CMV-seropositive patients; however, the differentiation of CD4 + T-lymphocytes was increased in CMV-seropositive but also in CHF patients. Anti-CMV antibody titers showed positive correlation with more differentiated CD4 + and CD8 + subsets and inverse correlation with CD4/CD8 ratio. Immunosenescence found in CHF patients is mainly due to the dynamics of CMV-infection, since the differentiation of T-lymphocyte subsets is related not only to CMV-infection, but also to anti-CMV antibody titers.

引用

页码：20 / 29

页数：10

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