Overlooked? Underestimated? Effects of Substrate Curvature on Cell Behavior

被引：121

作者：

Baptista, Danielle ^{[1
]}

Teixeira, Liliana ^{[1
,2
]}

van Blitterswijk, Clemens ^{[1
]}

Giselbrecht, Stefan ^{[1
]}

Truckenmuller, Roman ^{[1
]}

机构：

[1] Maastricht Univ, Dept Complex Tissue Regenerat, MERLN Inst Technol Inspired Regenerat Med, Univ Singel 40, NL-6229 ER Maastricht, Netherlands

[2] Univ Twente, Dept Dev BioEngn, Tech Med Ctr, Drienerlolaan 5, NL-7522 NB Enschede, Netherlands

来源：

TRENDS IN BIOTECHNOLOGY | 2019年 / 37卷 / 08期

基金：

欧盟地平线“2020”;

关键词：

STEM-CELLS; CONCAVE MICROWELLS; SELF-ORGANIZATION; CONTACT GUIDANCE; CDC42; GTPASES; DIFFERENTIATION; ORIENTATION; FABRICATION; SURFACE; PATTERNS;

D O I：

10.1016/j.tibtech.2019.01.006

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In biological systems, form and function are inherently correlated. Despite this strong interdependence, the biological effect of curvature has been largely overlooked or underestimated, and consequently it has rarely been considered in the design of new cell-material interfaces. This review summarizes current understanding of the interplay between the curvature of a cell substrate and the related morphological and functional cellular response. In this context, we also discuss what is currently known about how, in the process of such a response, cells recognize curvature and accordingly reshape their membrane. Beyond this, we highlight state-of-the-art microtechnologies for engineering curved biomaterials at cell-scale, and describe aspects that impair or improve read-outs of the pure effect of curvature on cells

引用

页码：838 / 854

页数：17

共 98 条

[1] Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells [J].