Medullary Thyroid Carcinoma: An Update on Imaging

被引:49
作者
Kushchayev, Sergiy V. [1 ,2 ]
Kushchayeva, Yevgeniya S. [3 ]
Tella, Sri Harsha [4 ]
Glushko, Tetiana [5 ]
Pacak, Karel [6 ]
Teytelboym, Oleg M. [5 ]
机构
[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Radiol, 12902 USF Magnolia Dr, Tampa, FL 33612 USA
[2] Johns Hopkins Univ Hosp, Dept Radiol, 601 N Caroline St, Baltimore, MD 21287 USA
[3] NIDDK, Diabet Endocrinol & Obes Branch, NIH, Bethesda 10,Ctr Dr, Bethesda, MD 20892 USA
[4] Univ South Carolina, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, 6311 Garners Ferry Rd, Columbia, SC USA
[5] Mercy Catholic Med Ctr, Dept Radiol, 1500 Lansdowne Ave, Darby, PA 19023 USA
[6] NICHD, Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA
基金
美国国家卫生研究院;
关键词
POSITRON-EMISSION-TOMOGRAPHY; FINE-NEEDLE-ASPIRATION; LIVER METASTASES; ASSOCIATION GUIDELINES; FOLLOW-UP; CLINICAL-APPLICATIONS; PULMONARY METASTASES; CALCITONIN LEVELS; F-18-FDG PET; CANCER;
D O I
10.1155/2019/1893047
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Medullary thyroid carcinoma (MTC), arising from the parafollicular C cells of the thyroid, accounts for 1-2% of thyroid cancers. MTC is frequently aggressive and metastasizes to cervical and mediastinal lymph nodes, lungs, liver, and bones. Although a number of new imaging modalities for directing the management of oncologic patients evolved over the last two decades, the clinical application of these novel techniques is limited in MTC. In this article, we review the biology and molecular aspects of MTC as an important background for the use of current imaging modalities and approaches for this tumor. We discuss the modern and currently available imaging techniques-advanced magnetic resonance imaging (MRI)-based techniques such as whole-body MRI, dynamic contrast-enhanced (DCE) technique, diffusion-weighted imaging (DWI), positron emission tomography/computed tomography (PET/CT) with 18F-FDOPA and 18F-FDG, and integrated positron emission tomography/magnetic resonance (PET/MR) hybrid imaging-for primary as well as metastatic MTC tumor, including its metastatic spread to lymph nodes and the most common sites of distant metastases: lungs, liver, and bones.
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页数:17
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