Coordination of circadian timing in mammals

被引：3413

作者：

Reppert, SM ^{[1
]}

Weaver, DR ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Neurobiol, Worcester, MA 01605 USA

来源：

NATURE | 2002年 / 418卷 / 6901期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature00965

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Time in the biological sense is measured by cycles that range from milliseconds to years. Circadian rhythms, which measure time on a scale of 24 h, are generated by one of the most ubiquitous and well-studied timing systems. At the core of this timing mechanism is an intricate molecular mechanism that ticks away in many different tissues throughout the body. However, these independent rhythms are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.

引用

页码：935 / 941

页数：7

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