HIV-1: Gambling on the evolution of drug resistance?

被引：71

作者：

Brown, AJL

Richman, DD

机构：

[1] UNIV CALIF SAN DIEGO, DEPT PATHOL, LA JOLLA, CA 92093 USA

[2] UNIV CALIF SAN DIEGO, DEPT MED, LA JOLLA, CA 92093 USA

[3] SAN DIEGO VET AFFAIRS MED CTR, LA JOLLA, CA 92093 USA

来源：

NATURE MEDICINE | 1997年 / 3卷 / 03期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; SYNCYTIUM-INDUCING PHENOTYPE; IN-VIVO; REVERSE-TRANSCRIPTASE; THERAPY; TYPE-1; INFECTION; ZIDOVUDINE; EMERGENCE; DISEASE;

D O I：

10.1038/nm0397-268

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite the huge size of the HIV population in an infected patient, chance has an unexpected influence on its evolution.

引用

页码：268 / 271

页数：4

共 43 条

[1] A CROSS-SECTIONAL COMPARISON OF PERSONS WITH SYNCYTIUM-INDUCING AND NON-SYNCYTIUM-INDUCING HUMAN-IMMUNODEFICIENCY-VIRUS [J].

BOZZETTE, SA ;

MCCUTCHAN, JA ;

SPECTOR, SA ;

WRIGHT, B ;

RICHMAN, DD .

JOURNAL OF INFECTIOUS DISEASES, 1993, 168 (06) :1374-1379

[2] HIV POPULATION-DYNAMICS IN-VIVO - IMPLICATIONS FOR GENETIC-VARIATION, PATHOGENESIS, AND THERAPY [J].

COFFIN, JM .

SCIENCE, 1995, 267 (5197) :483-489

[3] IN-VIVO EMERGENCE OF HIV-1 VARIANTS RESISTANT TO MULTIPLE PROTEASE INHIBITORS [J].

CONDRA, JH ;

SCHLEIF, WA ;

BLAHY, OM ;

GABRYELSKI, LJ ;

GRAHAM, DJ ;

QUINTERO, JC ;

RHODES, A ;

ROBBINS, HL ;

ROTH, E ;

SHIVAPRAKASH, M ;

TITUS, D ;

YANG, T ;

TEPPLER, H ;

SQUIRES, KE ;

DEUTSCH, PJ ;

EMINI, EA .

NATURE, 1995, 374 (6522) :569-571

[4] The variant call format and VCFtools [J].

Danecek, Petr ;

Auton, Adam ;

Abecasis, Goncalo ;

Albers, Cornelis A. ;

Banks, Eric ;

DePristo, Mark A. ;

Handsaker, Robert E. ;

Lunter, Gerton ;

Marth, Gabor T. ;

Sherry, Stephen T. ;

McVean, Gilean ;

Durbin, Richard .

BIOINFORMATICS, 2011, 27 (15) :2156-2158

[5]

DAQUILA RT, 1996, ANTIVIRAL DRUG RESIS, P191

[6] GENOMIC STRUCTURE OF AN ATTENUATED QUASI-SPECIES OF HIV-1 FROM A BLOOD-TRANSFUSION DONOR AND RECIPIENTS [J].

DEACON, NJ ;

TSYKIN, A ;

SOLOMON, A ;

SMITH, K ;

LUDFORDMENTING, M ;

HOOKER, DJ ;

MCPHEE, DA ;

GREENWAY, AL ;

ELLETT, A ;

CHATFIELD, C ;

LAWSON, VA ;

CROWE, S ;

MAERZ, A ;

SONZA, S ;

LEARMONT, J ;

SULLIVAN, JS ;

CUNNINGHAM, A ;

DWYER, D ;

DOWTON, D ;

MILLS, J .

SCIENCE, 1995, 270 (5238) :988-991

[7] NONHOMOGENEOUS DISTRIBUTION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROVIRUSES IN THE SPLEEN [J].

DELASSUS, S ;

CHEYNIER, R ;

WAINHOBSON, S .

JOURNAL OF VIROLOGY, 1992, 66 (09) :5642-5645

[8] RATES OF SPONTANEOUS MUTATION AMONG RNA VIRUSES [J].

DRAKE, JW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (09) :4171-4175

[9] NEW CONCEPTS FOR DEALING WITH THE EVOLUTION OF NUCLEIC-ACIDS [J].

EIGEN, M .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1987, 52 :307-320

[10] MASSIVE COVERT INFECTION OF HELPER T-LYMPHOCYTES AND MACROPHAGES BY HIV DURING THE INCUBATION PERIOD OF AIDS [J].

EMBRETSON, J ;

ZUPANCIC, M ;

RIBAS, JL ;

BURKE, A ;

RACZ, P ;

TENNERRACZ, K ;

HAASE, AT .

NATURE, 1993, 362 (6418) :359-362

← 1 2 3 4 5 →