Deuterium incorporation into reserpine

被引:1
作者
Lounasmaa, M [1 ]
Berner, M [1 ]
Tolvanen, A [1 ]
Jokela, R [1 ]
机构
[1] Helsinki Univ Technol, Organ & Bioorgan Chem Lab, FIN-02015 Espoo, Finland
关键词
D O I
10.3987/COM-99-S28
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Treatment of reserpine (1) with TFA-d under various conditions demonstrated that deuterium incorporation proceeds much more slowly than the epimerization. Indirect evidence was thereby obtained for the mechanism of the acid-catalysed epimerization of reserpine (1) that proceeds through C-3-N-b bond cleavage. Furthermore, the effectiveness of TFA as an epimerization reagent was demonstrated.
引用
收藏
页码:471 / 474
页数:4
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