Deuterium incorporation into reserpine

被引：1
|
作者：
Lounasmaa, M [1 ]
Berner, M [1 ]
Tolvanen, A [1 ]
Jokela, R [1 ]
机构：
[1] Helsinki Univ Technol, Organ & Bioorgan Chem Lab, FIN-02015 Espoo, Finland
来源：
HETEROCYCLES | 2000年 / 52卷 / 01期
关键词：
D O I：
10.3987/COM-99-S28
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of reserpine (1) with TFA-d under various conditions demonstrated that deuterium incorporation proceeds much more slowly than the epimerization. Indirect evidence was thereby obtained for the mechanism of the acid-catalysed epimerization of reserpine (1) that proceeds through C-3-N-b bond cleavage. Furthermore, the effectiveness of TFA as an epimerization reagent was demonstrated.
引用
收藏
页码：471 / 474
页数：4
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