CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis

被引：32

作者：

Van Nuffel, Elien ^{[1
,2
]}

Schmitt, Anja ^{[3
]}

Afonina, Inna S. ^{[1
,2
]}

Schulze-Osthoff, Klaus ^{[3
]}

Beyaert, Rudi ^{[1
,2
]}

Hailfinger, Stephan ^{[3
]}

机构：

[1] Univ Ghent VIB, Unit Mol Signal Transduct Inflammat, Inflammat Res Ctr, Technol Pk 927, B-9052 Ghent, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, Ghent, Belgium

[3] Eberhard Karls Univ Tuebingen, Interfac Inst Biochem, Tubingen, Germany

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2017年 / 137卷 / 03期

关键词：

NF-KAPPA-B; PITYRIASIS-RUBRA-PILARIS; GENERALIZED PUSTULAR PSORIASIS; T-CELL-ACTIVATION; PROTEASE ACTIVITY; CARD14; GENE; PHARMACOLOGICAL INHIBITION; SIGNALING PATHWAY; CHINESE COHORT; FAMILY MEMBER;

D O I：

10.1016/j.jid.2016.09.031

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Mutations in caspase recruitment domain-containing protein 14 (CARD14) have been linked to susceptibility to psoriasis. CARD14 is an intracellular scaffold protein that regulates proinflammatory gene expression. Recent studies have offered novel insights into the mechanisms of CARD14-mediated signaling in keratinocytes and the molecular impact of psoriasis-associated CARD14 mutations. CARD14 forms a signaling complex with BCL10 and the paracaspase MALT1, and this process is enhanced upon pathogenic CARD14 mutation, culminating in the activation of MALT1 protease activity and psoriasis-associated gene expression. This review summarizes the current knowledge of CARD14/MALT1-mediated signaling in keratinocytes and its therapeutic implications in psoriasis.

引用

页码：569 / 575

页数：7

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