Synthesis and fungicidal activity of 1,3,4-oxadiazol-2-yl thioether derivatives containing a phenazine-1-carboxylic acid scaffold

被引：14

作者：

Lu Xingliang ^{[1
]}

Zhu Xiang ^{[1
,2
]}

Zhang Min ^{[1
,2
]}

Wu Qinglai ^{[1
,2
]}

Zhou Xudong ^{[3
]}

Li Junkai ^{[1
,2
]}

机构：

[1] Yangtze Univ, Sch Agr, Jingzhou, Peoples R China

[2] Yangtze Univ, Inst Pesticides, Jingzhou, Peoples R China

[3] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 15期

关键词：

Phenazine-1-carboxylic acid (PCA); 1,3,4-oxadiazol-2-yl thioether; fungicidal activity; derivatives; synthesis; BIOACTIVITIES;

D O I：

10.1080/14786419.2018.1489389

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

To find new higher fungicidal activities lead compounds and develop new eco-friendly agrochemicals, natural product phenazine-1-carboxylic acid (PCA) as scaffold, a series of 1,3,4-oxadiazol-2-yl thioether derivatives was synthesized and bio-assayed. The results reveal that most target compounds possessed moderate to good fungicidal activities against R. solani, S. sclerotioru and P. oryzac Cavgra. Compounds 6n and 6o exhibit more than 90% bioactivity against S. sclerotioru. The EC50 value of compounds 6n and 6o are 11.16 and 30.47 mu M respectively, in particular, compound 6n show equal activity against S. sclerotioru to PCA (10.49 mu M). This result provides a valuable lead compound for further studies. [GRAPHICS] .

引用

收藏

页码：2145 / 2150

页数：6

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