Palladium-catalyzed direct arylation of maleimides: A simple route to bisaryl-substituted maleimides

被引：17

作者：

Jafarpour, Farnaz ^{[1
]}

Shamsianpour, Mitra ^{[1
]}

Issazadeh, Salumeh ^{[1
]}

Dorrani, Masoumeh ^{[1
]}

Hazrati, Hamideh ^{[1
]}

机构：

[1] Univ Tehran, Coll Sci, Sch Chem, P Box 14155-6455, Tehran, Iran

来源：

TETRAHEDRON | 2017年 / 73卷 / 13期

关键词：

Boronic acids; Direct arylation; Maleimide; Oxidative Heck reaction; Palladium; LIGHT-EMITTING-DIODES; BIOLOGICAL EVALUATION; CONVENIENT SYNTHESIS; EFFICIENT SYNTHESIS; 3,4-DIARYLMALEIMIDES; FLUORESCENCE; DOCKING; ALKYNES; POTENT;

D O I：

10.1016/j.tet.2017.01.069

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium-catalyzed direct arylation of maleimides via Heck as well as organoboron-mediated Heck-type reactions are developed. These methods offer an approach to a wide variety of biologically interesting 3,4-diarylmaleimide scaffolds from readily accessible starting materials. These approaches led to the feasible one-pot construction of bisaryl-substituted maleimides which have historically been problematic. (C) 2017 Published by Elsevier Ltd.

引用

页码：1668 / 1672

页数：5

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