Regenerative capacity of autologous stem cell transplantation in elderly: a report of biomedical outcomes

被引：10
作者：
Gonzalez-Garza, Maria Teresa [1 ]
Cruz-Vega, Delia Elva [1 ]
机构：
[1] Escuela Nacl Med, Tecnol Monterrey, Morones Prieto 3000 Pte, Monterrey 64710, Mexico
来源：
REGENERATIVE MEDICINE | 2017年 / 12卷 / 02期
关键词：
adult stem cells; aging; autologous transplantation; clinical trial; elderly patients; AMYOTROPHIC-LATERAL-SCLEROSIS; MESENCHYMAL STROMAL CELLS; ACUTE MYOCARDIAL-INFARCTION; LEFT-VENTRICULAR FUNCTION; MARROW MONONUCLEAR-CELLS; BONE-MARROW; ADIPOSE-TISSUE; MULTIPLE-SCLEROSIS; ISCHEMIC-STROKE; CLINICAL-TRIAL;
D O I：
10.2217/rme-2016-0038
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The occurrence of chronic diseases such as neurological, metabolic and cardiovascular degenerative disorders increases with age. Cell therapy is an emerging approach to the treatment of these conditions. Of particular interest is the application of autologous stem cells because it eliminates post-transplantation immune rejection and there are less ethical concerns associated with their use. The regenerative capacity of stem cells harvested from elderly people is however controversial. In this review, we analyze if self-renewal potential, differentiation capability and expression of stemness genes in stem cells collected from elderly patients validate their application in clinical trials and examine the results.
引用
收藏
页码：169 / 178
页数：10
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