Real-time optoacoustic tomography of indocyanine green perfusion and oxygenation parameters in human finger vasculature

被引：38

作者：

Lutzweiler, Christian ^{[1
,2
]}

Meier, Reinhard ^{[3
,4
]}

Rummeny, Ernst ^{[3
,4
]}

Ntziachristos, Vasilis ^{[1
,2
,3
]}

Razansky, Daniel ^{[1
,3
]}

机构：

[1] Helmholtz Zentrum Munchen, Inst Biol & Med Imaging, Neuherberg, Germany

[2] Tech Univ Munich, Dept Elect Engn & Informat Technol, D-80290 Munich, Germany

[3] Tech Univ Munich, Fac Med, D-80290 Munich, Germany

[4] Tech Univ Munich, Klinikum Rechts Isar, Dept Radiol, D-80290 Munich, Germany

来源：

OPTICS LETTERS | 2014年 / 39卷 / 14期

关键词：

PHOTOACOUSTIC TOMOGRAPHY; SYNOVITIS; BREAST;

D O I：

10.1364/OL.39.004061

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We interrogated whether optoacoustic tomography could be employed to study blood functional parameters and biodistribution of injected fluorescent agents in humans. Using a multichannel scanner at a frame rate of 10 images per second, we obtained cross-sectional images of the human finger in real time, before and after the administration of indocyanine green. We demonstrated that multispectral optoacoustic tomography can sense fast flow kinetics and resolve spatiotemporal characteristics of a common fluorochrome in human vasculature at clinically relevant concentrations. We further register ICG images with oxygen saturation maps and anatomical views of the proximal interphalangeal joint of a healthy volunteer. (C) 2014 Optical Society of America

引用

页码：4061 / 4064

页数：4

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