Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2

被引：247
作者：
Lawrie, AM
Noble, MEM
Tunnah, P
Brown, NR
Johnson, LN
Endicott, JA
机构：
[1] UNIV OXFORD, MOL BIOPHYS LAB, OXFORD OX1 3QU, ENGLAND
[2] OXFORD CTR MOL SCI, OXFORD OX1 3QU, ENGLAND
来源：
NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 10期
关键词：
D O I：
10.1038/nsb1097-796
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 strauroporine complex explains the tight binding of this inhibitor and suggests features to be exploited in the design of specific inhibitors of CDKs.
引用
收藏
页码：796 / 801
页数：6
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