Characterizing the Mesencephalon Using Susceptibility-Weighted Imaging
被引:49
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作者:
Manova, E. S.
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机构:
Wayne State Univ, Dept Biomed Engn, Detroit, MI USAMRI Inst Biomed Res, Detroit, MI 48202 USA
Manova, E. S.
[2
]
Habib, C. A.
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机构:
MRI Inst Biomed Res, Detroit, MI 48202 USA
Wayne State Univ, Dept Biomed Engn, Detroit, MI USAMRI Inst Biomed Res, Detroit, MI 48202 USA
Habib, C. A.
[1
,2
]
Boikov, A. S.
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MRI Inst Biomed Res, Detroit, MI 48202 USAMRI Inst Biomed Res, Detroit, MI 48202 USA
Boikov, A. S.
[1
]
Ayaz, M.
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机构:
MRI Inst Biomed Res, Detroit, MI 48202 USA
Wayne State Univ, Dept Biomed Engn, Detroit, MI USAMRI Inst Biomed Res, Detroit, MI 48202 USA
Ayaz, M.
[1
,2
]
Khan, A.
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机构:
Wayne State Univ, Dept Biomed Engn, Detroit, MI USAMRI Inst Biomed Res, Detroit, MI 48202 USA
Khan, A.
[2
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Kirsch, W. M.
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机构:
Loma Linda Univ, Dept Neurosurg, Loma Linda, CA 92350 USAMRI Inst Biomed Res, Detroit, MI 48202 USA
Kirsch, W. M.
[4
]
Kido, D. K.
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机构:
Loma Linda Univ, Dept Radiol, Loma Linda, CA 92350 USAMRI Inst Biomed Res, Detroit, MI 48202 USA
Kido, D. K.
[3
]
Haacke, E. M.
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机构:
MRI Inst Biomed Res, Detroit, MI 48202 USA
Wayne State Univ, Dept Biomed Engn, Detroit, MI USA
Loma Linda Univ, Dept Radiol, Loma Linda, CA 92350 USAMRI Inst Biomed Res, Detroit, MI 48202 USA
Haacke, E. M.
[1
,2
,3
]
机构:
[1] MRI Inst Biomed Res, Detroit, MI 48202 USA
[2] Wayne State Univ, Dept Biomed Engn, Detroit, MI USA
[3] Loma Linda Univ, Dept Radiol, Loma Linda, CA 92350 USA
[4] Loma Linda Univ, Dept Neurosurg, Loma Linda, CA 92350 USA
BACKGROUND AND PURPOSE: The mesencephalon is involved in a number of human neurodegenerative disorders and has been typically imaged with T1-, T2- and T2*-weighted methods. Our aim was to collect high-contrast susceptibility-weighted imaging (SWI) data to differentiate among and within the basic mesencephalic structures: namely, the red nucleus, substantia nigra, and crus cerebri. MATERIALS AND METHODS: High-resolution SWI, 3D T1-weighted, and T2-weighted data were collected to study contrast in the mesencephalon at 1.5T and 4T. Contrast between structures was calculated for SWI high-pass (HP)-filtered-phase, T1 gradient-echo, and spin-echo T2-weighted data. RESULTS: SWI HP-filtered-phase data revealed similar contrast for the red nucleus and substantia nigra when compared with T2-weighted imaging. However, SWI was able to show structures within the red nucleus, substantia nigra, and medial geniculate body that were invisible on T2-weighted imaging. T1-weighted imaging, on the other hand, did not reveal measurable contrast for any of the structures of interest. SWI HP-filtered-phase data at 4T agreed well with india ink-stained cadaver brain studies, which appear to correlate with capillary density. CONCLUSIONS: With SWI, it is possible to create better anatomic images of the mesencephalon, with improved contrast compared with conventional T1- or T2-weighted sequences.