Characterizing the Mesencephalon Using Susceptibility-Weighted Imaging

被引:49
|
作者
Manova, E. S. [2 ]
Habib, C. A. [1 ,2 ]
Boikov, A. S. [1 ]
Ayaz, M. [1 ,2 ]
Khan, A. [2 ]
Kirsch, W. M. [4 ]
Kido, D. K. [3 ]
Haacke, E. M. [1 ,2 ,3 ]
机构
[1] MRI Inst Biomed Res, Detroit, MI 48202 USA
[2] Wayne State Univ, Dept Biomed Engn, Detroit, MI USA
[3] Loma Linda Univ, Dept Radiol, Loma Linda, CA 92350 USA
[4] Loma Linda Univ, Dept Neurosurg, Loma Linda, CA 92350 USA
基金
美国国家卫生研究院;
关键词
STRUCTURAL-CHANGES; IRON; MIDBRAIN; CONTRAST; IMAGES;
D O I
10.3174/ajnr.A1401
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
BACKGROUND AND PURPOSE: The mesencephalon is involved in a number of human neurodegenerative disorders and has been typically imaged with T1-, T2- and T2*-weighted methods. Our aim was to collect high-contrast susceptibility-weighted imaging (SWI) data to differentiate among and within the basic mesencephalic structures: namely, the red nucleus, substantia nigra, and crus cerebri. MATERIALS AND METHODS: High-resolution SWI, 3D T1-weighted, and T2-weighted data were collected to study contrast in the mesencephalon at 1.5T and 4T. Contrast between structures was calculated for SWI high-pass (HP)-filtered-phase, T1 gradient-echo, and spin-echo T2-weighted data. RESULTS: SWI HP-filtered-phase data revealed similar contrast for the red nucleus and substantia nigra when compared with T2-weighted imaging. However, SWI was able to show structures within the red nucleus, substantia nigra, and medial geniculate body that were invisible on T2-weighted imaging. T1-weighted imaging, on the other hand, did not reveal measurable contrast for any of the structures of interest. SWI HP-filtered-phase data at 4T agreed well with india ink-stained cadaver brain studies, which appear to correlate with capillary density. CONCLUSIONS: With SWI, it is possible to create better anatomic images of the mesencephalon, with improved contrast compared with conventional T1- or T2-weighted sequences.
引用
收藏
页码:569 / 574
页数:6
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