Artificial metalloenzymes for enantioselective catalysis

被引：119

作者：

Bos, Jeffrey ^{[1
]}

Roelfes, Gerard ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2014年 / 19卷

关键词：

BIOTIN-STREPTAVIDIN TECHNOLOGY; DIELS-ALDER REACTIONS; ASYMMETRIC CATALYSIS; TRANSFER HYDROGENATION; H ACTIVATION; DNA; COMPLEXES; PROTEIN; ENZYME; SITE;

D O I：

10.1016/j.cbpa.2014.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Artificial metalloenzymes have emerged over the last decades as an attractive approach towards combining homogeneous catalysis and biocatalysis. A wide variety of catalytic transformations have been established by artificial metalloenzymes, thus establishing proof of concept. The field is now slowly transforming to take on new challenges. These include novel designs, novel catalytic reactions, some of which have no equivalent in both homogenous catalysis and biocatalysis and the incorporation of artificial metalloenzymes in chemoenzymatic cascades. Some of these developments represent promising steps towards integrating artificial metalloenzymes in biological systems. This review will focus on advances in this field and perspectives discussed.

引用

页码：135 / 143

页数：9

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