Three new isobenzofurans from Lavandula angustifolia and their bioactivities

被引：4
作者：
Zhou, Min [1 ,2 ,3 ,4 ]
Xing, Huan-Huan [1 ,2 ,4 ]
Ma, Hang-Ying [1 ,2 ,4 ]
Zhou, Lin [1 ,2 ,4 ]
Yang, Yan [1 ,2 ,4 ]
Li, Gan-Peng [1 ,2 ,4 ]
Hu, Wei-Yao [3 ]
Liu, Qiang [3 ]
Li, Xue-Mei [3 ]
Hu, Qiu-Fen [1 ,2 ,4 ]
机构：
[1] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
[2] Yunnan Minzu Univ, Minist Educ, Kunming 650031, Peoples R China
[3] China Tobacco Yunnan Ind Co Ltd, Ctr Technol, Kunming 650000, Peoples R China
[4] Yunnan Minzu Univ, Sch Ethn Med, Kunming 650031, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2017年 / 19卷
基金：
中国国家自然科学基金;
关键词：
Lavandula angustifolia; Isobenzofurans; Anti-tobacco mosaic virus activity; Cytotoxicity; NICOTIANA-TABACUM; LAVENDER; EXTRACTS; LEAVES;
D O I：
10.1016/j.phytol.2016.12.034
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new isobenzofurans, lavandulactones A-C (1-3), together with three known ones (4-6), were isolated from the whole herb of Lavandula angustifolia. Their structures were established on the basis of detailed spectroscopic analysis (1D-and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New isolates were evaluated for their anti-tobacco mosaic virus (TMV) activities and cytotoxicity activities. The results revealed that compounds 1-3 showed high anti-TMV activity with inhibition rate of 31.8, 29.6 and 33.4%, respectively. These rates are higher than that of positive control. Compounds 1-3 also showed weak inhibitory activities against some tested human tumor cell lines with IC50 values ranging from 1.5 to 5.7 mu M. (C) 2016 Published by Elsevier Ltd on behalf of Phytochemical Society of Europe.
引用
收藏
页码：156 / 159
页数：4
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