Integration of ChREBP-Mediated Glucose Sensing into Whole Body Metabolism

被引：45

作者：

Baraille, Floriane ^{[1
,2
,3
]}

Planchais, Julien ^{[1
,2
,3
]}

Dentin, Renaud ^{[1
,2
,3
]}

Guilmeau, Sandra ^{[1
,2
,3
]}

Postic, Catherine ^{[1
,2
,3
]}

机构：

[1] Inst Cochin Genet Mol, INSERM, U1016, F-75014 Paris, France

[2] CNRS, UMR 8104, Paris, France

[3] Univ Paris 05, Paris, France

来源：

PHYSIOLOGY | 2015年 / 30卷 / 06期

关键词：

CARBOHYDRATE RESPONSE ELEMENT; THIOREDOXIN-INTERACTING PROTEIN; PYRUVATE-KINASE GENE; WILLIAMS-BEUREN-SYNDROME; TUBULE NA+/H+ EXCHANGE; TRANSCRIPTION FACTOR; BINDING PROTEIN; INSULIN-RESISTANCE; HEPATIC STEATOSIS; FATTY-ACID;

D O I：

10.1152/physiol.00016.2015

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Since glucose is the principal energy source for most cells, many organisms have evolved numerous and sophisticated mechanisms to sense glucose and respond to it appropriately. In this context, cloning of the carbohydrate responsive element binding protein has unraveled a critical molecular link between glucose metabolism and transcriptional reprograming induced by glucose. In this review, we detail major findings that have advanced our knowledge of glucose sensing.

引用

页码：428 / 437

页数：10

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