MyD88 and IL-1: Loosening Treg cells' firm grip

被引：4

作者：

Campbell, Daniel J. ^{[1
,2
]}

机构：

[1] Benaroya Res Inst, Seattle, WA 98101 USA

[2] Univ Washington, Sch Med, Dept Immunol, Seattle, WA USA

来源：

TRENDS IN IMMUNOLOGY | 2014年 / 35卷 / 03期

关键词：

RESPONSES;

D O I：

10.1016/j.it.2014.02.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune suppression by T-reg cells must be overcome to mount robust and effective anti-pathogen immune responses. A new paper in Immunity from Medzhitov and colleagues shows that IL-1-dependent activation of MyD88 promotes the development of Th1 cells by rendering them impervious to T-reg cell-mediated inhibition.

引用

页码：95 / 96

页数：2

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