MyD88 and IL-1: Loosening Treg cells' firm grip

被引:3
作者
Campbell, Daniel J. [1 ,2 ]
机构
[1] Benaroya Res Inst, Seattle, WA 98101 USA
[2] Univ Washington, Sch Med, Dept Immunol, Seattle, WA USA
关键词
RESPONSES;
D O I
10.1016/j.it.2014.02.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immune suppression by T-reg cells must be overcome to mount robust and effective anti-pathogen immune responses. A new paper in Immunity from Medzhitov and colleagues shows that IL-1-dependent activation of MyD88 promotes the development of Th1 cells by rendering them impervious to T-reg cell-mediated inhibition.
引用
收藏
页码:95 / 96
页数:2
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