MyD88 and IL-1: Loosening Treg cells' firm grip

被引：3

作者：

Campbell, Daniel J. ^{[1
,2
]}

机构：

[1] Benaroya Res Inst, Seattle, WA 98101 USA

[2] Univ Washington, Sch Med, Dept Immunol, Seattle, WA USA

来源：

TRENDS IN IMMUNOLOGY | 2014年 / 35卷 / 03期

关键词：

RESPONSES;

D O I：

10.1016/j.it.2014.02.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune suppression by T-reg cells must be overcome to mount robust and effective anti-pathogen immune responses. A new paper in Immunity from Medzhitov and colleagues shows that IL-1-dependent activation of MyD88 promotes the development of Th1 cells by rendering them impervious to T-reg cell-mediated inhibition.

引用

页码：95 / 96

页数：2

共 11 条

[1] Phenotypical and functional specialization of FOXP3+ regulatory T cells [J].

Campbell, Daniel J. ;

Koch, Meghan A. .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (02) :119-130

[2] Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling [J].

Chung, Yeonseok ;

Chang, Seon Hee ;

Martinez, Gustavo J. ;

Yang, Xuexian O. ;

Nurieva, Roza ;

Kang, Hong Soon ;

Ma, Li ;

Watowich, Stephanie S. ;

Jetten, Anton M. ;

Tian, Qiang ;

Dong, Chen .

IMMUNITY, 2009, 30 (04) :576-587

[3]

HOLSTI MA, 1994, J IMMUNOL, V152, P1618

[4]

Joseph SB, 1998, EUR J IMMUNOL, V28, P277, DOI 10.1002/(SICI)1521-4141(199801)28:01<277::AID-IMMU277>3.3.CO

[5]

2-#

[6] Signaling through the Adaptor Molecule MyD88 in CD4+ T Cells Is Required to Overcome Suppression by Regulatory T Cells [J].

Schenten, Dominik ;

Nish, Simone A. ;

Yu, Shuang ;

Yan, Xiting ;

Lee, Heung Kyu ;

Brodsky, Igor ;

Pasman, Lesley ;

Yordy, Brian ;

Wunderlich, F. Thomas ;

Bruening, Jens C. ;

Zhao, Hongyu ;

Medzhitov, Ruslan .

IMMUNITY, 2014, 40 (01) :78-90

[7] The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells [J].

Schneider, Anya ;

Rieck, Mary ;

Sanda, Srinath ;

Pihoker, Catherine ;

Greenbaum, Carla ;

Buckner, Jane H. .

JOURNAL OF IMMUNOLOGY, 2008, 181 (10) :7350-7355

[8] In Active Relapsing-Remitting Multiple Sclerosis, Effector T Cell Resistance to Adaptive Tregs Involves IL-6-Mediated Signaling [J].

Schneider, Anya ;

Long, Sarah Alice ;

Cerosaletti, Karen ;

Ni, Chester T. ;

Samuels, Peter ;

Kita, Mariko ;

Buckner, Jane Hoyt .

SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (170)

[9] The IL-1 family: regulators of immunity [J].

Sims, John E. ;

Smith, Dirk E. .

NATURE REVIEWS IMMUNOLOGY, 2010, 10 (02) :89-102

[10] How regulatory T cells work [J].

Vignali, Dario A. A. ;

Collison, Lauren W. ;

Workman, Creg J. .

NATURE REVIEWS IMMUNOLOGY, 2008, 8 (07) :523-532

← 1 2 →