Drug Delivery by an Enzyme-Mediated Cyclization of a Lipid Prodrug with Unique Bilayer-Formation Properties

被引：65

作者：

Linderoth, Lars ^{[2
]}

Peters, Guenther H. ^{[2
]}

Madsen, Robert ^{[2
]}

Andresen, Thomas L. ^{[1
]}

机构：

[1] Tech Univ Denmark, Dept Micro & Nanotechnol, DK-4000 Roskilde, Denmark

[2] Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

cyclization; drug delivery; liposomes; phospholipase; prodrugs; SECRETORY PHOSPHOLIPASE A(2); CANCER-THERAPY; ACTIVATION; RELEASE; LIPOSOMES; PROSPECTS; ANALOGS;

D O I：

10.1002/anie.200805241

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Special delivery: Liposomal drug-delivery systems in which prodrugs are activated specifically by disease-associated enzymes have great potential for the treatment of severe diseases, such as cancer. A new type of phospholipid-based prodrug has the ability to form stable small unilamellar vesicles (see picture). Activation of the prodrug vesicles by the enzyme sPLA2 initiates a cyclization reaction, which leads to the release of the drug. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1823 / 1826

页数：4

共 25 条

[1]

Abe T, 1997, INT J CANCER, V74, P245, DOI 10.1002/(SICI)1097-0215(19970620)74:3<245::AID-IJC2>3.0.CO

[2]

2-Z

[3] Drug delivery systems: Entering the mainstream [J].

Allen, TM ;

Cullis, PR .

SCIENCE, 2004, 303 (5665) :1818-1822

[4] Synthesis of anti-tumour phosphatidylinositol analogues from glucose by the use of ring-closing olefin metathesis [J].

Andresen, TL ;

Skytte, DM ;

Madsen, R .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2004, 2 (20) :2951-2957

[5] Enzymatic release of antitumor ether lipids by specific phospholipase A2 activation of liposome-forming prodrugs [J].

Andresen, TL ;

Davidsen, J ;

Begtrup, M ;

Mouritsen, OG ;

Jorgensen, K .

JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (07) :1694-1703

[6] Advanced strategies in liposomal cancer therapy: Problems and prospects of active and tumor specific drug release [J].

Andresen, TL ;

Jensen, SS ;

Jorgensen, K .

PROGRESS IN LIPID RESEARCH, 2005, 44 (01) :68-97

[7] Liposome application: problems and prospects [J].

Barenholz, Y .

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2001, 6 (01) :66-77

[8] THE SYNTHESIS OF SPECIFIC RIBONUCLEOTIDES AND UNRELATED PHOSPHORYLATED BIOMOLECULES BY THE PHOSPHORAMIDITE METHOD [J].

BEAUCAGE, SL ;

IYER, RP .

TETRAHEDRON, 1993, 49 (46) :10441-10488

[9] Polymer vesicles [J].

Discher, DE ;

Eisenberg, A .

SCIENCE, 2002, 297 (5583) :967-973

[10] Current status of pH-sensitive liposomes in drug delivery [J].

Drummond, DC ;

Zignani, M ;

Leroux, JC .

PROGRESS IN LIPID RESEARCH, 2000, 39 (05) :409-460

← 1 2 3 →