Maternal Obesity, Inflammation, and Developmental Programming

被引:141
作者
Segovia, Stephanie A. [1 ]
Vickers, Mark H. [1 ]
Gray, Clint [1 ]
Reynolds, Clare M. [1 ]
机构
[1] Univ Auckland, Natl Ctr Growth & Dev, Liggins Inst & Gravida, Auckland 1142, New Zealand
关键词
NF-KAPPA-B; POLYUNSATURATED FATTY-ACIDS; ACTIVATED-RECEPTOR-GAMMA; ADIPOSE-TISSUE INFLAMMATION; TUMOR-NECROSIS-FACTOR; DIET-INDUCED OBESITY; INSULIN-RESISTANCE; SKELETAL-MUSCLE; GENE-EXPRESSION; METABOLIC SYNDROME;
D O I
10.1155/2014/418975
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The prevalence of obesity, especially in women of child-bearing age, is a global health concern. In addition to increasing the immediate risk of gestational complications, there is accumulating evidence thatmaternal obesity also has long-termconsequences for the offspring. The concept of developmental programming describes the process in which an environmental stimulus, including altered nutrition, during critical periods of development can program alterations in organogenesis, tissue development, and metabolism, predisposing offspring to obesity and metabolic and cardiovascular disorders in later life. Although the mechanisms underpinning programming of metabolic disorders remain poorly defined, it has become increasingly clear that low-grade inflammation is associated with obesity and its comorbidities. This review will discuss maternal metainflammation as amediator of programming in insulin sensitive tissues in offspring. Use of nutritional anti-inflammatories in pregnancy including omega 3 fatty acids, resveratrol, curcumin, and taurine may provide beneficial intervention strategies to ameliorate maternal obesity-induced programming.
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页数:14
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