Hippo pathway deregulation: implications in the pathogenesis of haematological malignancies

被引：3
作者：
Cacemiro, Maira da Costa [1 ]
Berzoti-Coelho, Maria Gabriela [1 ]
Cominal, Jucara Gastaldi [1 ]
Burin, Sandra Mara [1 ]
de Castro, Fabiola Attie [1 ]
机构：
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Food Sci, Sao Paulo, Brazil
来源：
JOURNAL OF CLINICAL PATHOLOGY | 2017年 / 70卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
MESSENGER-RNA EXPRESSION; YES-ASSOCIATED PROTEIN; TUMOR-SUPPRESSOR; CELL-PROLIFERATION; DOWN-REGULATION; YAP; APOPTOSIS; DROSOPHILA; GENE; PROMOTES;
D O I：
10.1136/jclinpath-2016-204055
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The Hippo pathway participates in the regulation of cell proliferation, differentiation and apoptosis. It is composed by a large array of proteins whose deregulation has been associated with pro-oncogenic and antioncogenic processes. The present review focuses on the Hippo pathway signalling network and discusses its dual role in oncogenesis, particularly in haematological malignancies.
引用
收藏
页码：9 / 14
页数：6
相关论文
共 65 条
  • [1] Hippo signaling: to die or not to die
    Aqeilan, R. I.
    [J]. CELL DEATH AND DIFFERENTIATION, 2013, 20 (10) : 1287 - 1288
  • [2] A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
    Aylon, Yael
    Michael, Dan
    Shmueli, Ayelet
    Yabuta, Norikazu
    Nojima, Hiroshi
    Oren, Moshe
    [J]. GENES & DEVELOPMENT, 2006, 20 (19) : 2687 - 2700
  • [3] Histone Acetylation-Mediated Regulation of the Hippo Pathway
    Basu, Dipanjan
    Reyes-Mugica, Miguel
    Rebbaa, Abdelhadi
    [J]. PLOS ONE, 2013, 8 (05):
  • [4] Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
    Basu, S
    Totty, NF
    Irwin, MS
    Sudol, M
    Downward, J
    [J]. MOLECULAR CELL, 2003, 11 (01) : 11 - 23
  • [5] RASSF2 associates with and stabilizes the proapoptotic kinase MST2
    Cooper, W. N.
    Hesson, L. B.
    Matallanas, D.
    Dallol, A.
    von Kriegsheim, A.
    Ward, R.
    Kolch, W.
    Latif, F.
    [J]. ONCOGENE, 2009, 28 (33) : 2988 - 2998
  • [6] Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers
    Cottini, Francesca
    Hideshima, Teru
    Xu, Chunxiao
    Sattler, Martin
    Dori, Martina
    Agnelli, Luca
    ten Hacken, Elisa
    Bertilaccio, Maria Teresa
    Antonini, Elena
    Neri, Antonino
    Ponzoni, Maurilio
    Marcatti, Magda
    Richardson, Paul G.
    Carrasco, Ruben
    Kimmelman, Alec C.
    Wong, Kwok-Kin
    Caigaris-Cappio, Federico
    Blandino, Giovanni
    Kuehl, W. Michael
    Anderson, Kenneth C.
    Tonon, Giovanni
    [J]. NATURE MEDICINE, 2014, 20 (06) : 599 - 606
  • [7] Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions
    Couzens, Amber L.
    Knight, James D. R.
    Kean, Michelle J.
    Teo, Guoci
    Weiss, Alexander
    Dunham, Wade H.
    Lin, Zhen-Yuan
    Bagshaw, Richard D.
    Sicheri, Frank
    Pawson, Tony
    Wrana, Jeffrey L.
    Choi, Hyungwon
    Gingras, Anne-Claude
    [J]. SCIENCE SIGNALING, 2013, 6 (302) : rs15
  • [8] TAZ/WWTR1 is overexpressed in papillary thyroid carcinoma
    de Cristofaro, Tiziana
    Di Palma, Tina
    Ferraro, Angelo
    Corrado, Alessia
    Lucci, Valeria
    Franco, Renato
    Fusco, Alfredo
    Zannini, Mariastella
    [J]. EUROPEAN JOURNAL OF CANCER, 2011, 47 (06) : 926 - 933
  • [9] ANKHD1 regulates cell cycle progression and proliferation in multiple myeloma cells
    Dhyani, Anamika
    Duarte, Adriana S. S.
    Machado-Neto, Joao A.
    Favaro, Patricia
    Ortega, Manoela Marques
    Olalla Saad, Sara T.
    [J]. FEBS LETTERS, 2012, 586 (24) : 4311 - 4318
  • [10] Control of Proliferation and Cancer Growth by the Hippo Signaling Pathway
    Ehmer, Ursula
    Sage, Julien
    [J]. MOLECULAR CANCER RESEARCH, 2016, 14 (02) : 127 - 140
1234567