Synapsins regulate α-synuclein functions

被引:67
作者
Atias, Merav [1 ,2 ]
Tevet, Yaara [1 ,2 ]
Sun, Jichao [3 ]
Stavsky, Alexandra [1 ,2 ]
Tal, Shani [1 ,2 ]
Kahn, Joy [1 ]
Roy, Subhojit [3 ,4 ]
Gitler, Daniel [1 ,2 ]
机构
[1] Ben Gurion Univ Negev, Dept Physiol & Cell Biol, Fac Hlth Sci, IL-84105 Beer Sheva, Israel
[2] Ben Gurion Univ Negev, Zlotowski Ctr Neurosci, IL-84105 Beer Sheva, Israel
[3] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53705 USA
[4] Univ Wisconsin, Dept Neurosci, Madison, WI 53705 USA
基金
以色列科学基金会;
关键词
alpha synuclein; synapsin; neurotransmission; MICE LACKING; OVEREXPRESSION; MOBILITY; VESICLES; RELEASE;
D O I
10.1073/pnas.1903054116
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The normal function of alpha-synuclein (alpha-syn) remains elusive. Although recent studies suggest alpha-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin-a cytosolic protein with known roles in SV mobilization and clustering-is required for presynaptic functions of alpha-syn. Our data offer a critical missing link and advocate a model where alpha-syn and synapsin cooperate to cluster SVs and attenuate recycling.
引用
收藏
页码:11116 / 11118
页数:3
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