Overexpression of Wnt-2 in colorectal cancers

被引：35

作者：

Park, J. K. ^{[2
]}

Song, J. H. ^{[1
]}

He, T. C.

Nam, S. W. ^{[1
]}

Lee, J. Y. ^{[1
]}

Park, W. S. ^{[1
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Pathol, Seoul 137701, South Korea

[2] Catholic Univ Korea, Dept Surg, Coll Med, Seoul 137701, South Korea

来源：

NEOPLASMA | 2009年 / 56卷 / 02期

关键词：

Wnt-2; protein; expression; immunohistochemistry; tissue microarray; colon cancer; HUMAN-COLON-CANCER; BETA-CATENIN; GASTRIC-CANCER; CELLS; INHIBITION; EXPRESSION; RECEPTOR; APOPTOSIS; PATHWAY; GROWTH;

D O I：

10.4149/neo_2009_02_119

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The binding of the Wnt ligand to its receptor Frizzled. activates the Wnt canonical signaling pathway in carcinogenesis as well as many cellular processes, including cellular proliferation and differentiation. Wnt-2, one of 19 members of the Wnt gene family, is frequently overexpressed in malignant tissues. Here, in order to investigate the role of Wnt-2 in colorectal carcinogenesis, we examined the expression of the Wnt-2 protein in 120 colorectal cancers by immunohistochemistry. Wnt-2 protein was expressed in the cell membrane and cytoplasm and up-regulated in 74 (61.7%) of 120 colorectal cancers. Statistically, overexpression of Wnt-2 protein was not associated with the clinical and pathological parameters studied, including tumor location, tumor size, clinical stage, lymph node metastasis, and 5-year Survival (P > 0.05). These results indicate that up-regulation of the Wnt-2 protein might play a role in the development of colorectal cancers, as an early event of carcinogenesis.

引用

页码：119 / 123

页数：5

共 27 条

[1] The Wnt antagonist DICKKOPF-1 gene is induced by 1α,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells [J].