Metastatic disease from uveal melanoma: treatment options and future prospects

被引：290

作者：

Carvajal, Richard D. ^{[1
]}

Schwartz, Gary K. ^{[1
]}

Tezel, Tongalp ^{[2
]}

Marr, Brian ^{[3
]}

Francis, Jasmine H. ^{[3
]}

Nathan, Paul D. ^{[4
]}

机构：

[1] Columbia Univ, Div Hematol Oncol, Med Ctr, New York, NY 10032 USA

[2] Columbia Univ, Dept Ophthalmol, Med Ctr, New York, NY 10027 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USA

[4] Mt Vernon Canc Ctr, Div Canc Serv, Northwood, Middx, England

来源：

BRITISH JOURNAL OF OPHTHALMOLOGY | 2017年 / 101卷 / 01期

关键词：

MEK INHIBITOR TRAMETINIB; AZD6244; ARRY-142886; MALIGNANT MELANOMAS; GERMLINE MUTATIONS; HEPATIC METASTASES; SOMATIC MUTATIONS; REGULATED KINASE; CELL-GROWTH; OPEN-LABEL; BRAF GENE;

D O I：

10.1136/bjophthalmol-2016-309034

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Uveal melanoma represents similar to 85% of all ocular melanomas and up to 50% of patients develop metastatic disease. Metastases are most frequently localised to the liver and, as few patients are candidates for potentially curative surgery, this is associated with a poor prognosis. There is currently little published evidence for the optimal management and treatment of metastatic uveal melanoma and the lack of effective therapies in this setting has led to the widespread use of systemic treatments for patients with cutaneous melanoma. Uveal and cutaneous melanomas are intrinsically different diseases and so dedicated management strategies and therapies for uveal melanoma are much needed. This review explores the biology of uveal melanoma and how this relates to ongoing trials of targeted therapies in the metastatic disease setting. In addition, we consider the options to optimise patient management and care.

引用

页码：38 / 44

页数：7

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