Cross-dehydrogenative coupling of 3,6-dihydro-2H-pyrans with 1,3-dicarbonyls and aryl moieties

被引：4

作者：

Feng, Guidong ^{[1
]}

Sun, Chuanxi ^{[1
]}

Xin, Xiaodong ^{[2
]}

Wan, Renzhong ^{[1
]}

Liu, Lei ^{[2
]}

机构：

[1] Shandong Agr Univ, Coll Anim Sci & Vet Med, Tai An 271018, Shandong, Peoples R China

[2] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 23期

关键词：

Cross-dehydrogenative coupling; 3,6-Dihydro-2H-pyran; 1,3-Dicarbonyl; Aryl ring; C-H FUNCTIONALIZATION; TERTIARY-AMINES; STRUCTURALLY DIVERSE; BONDS ADJACENT; ASYMMETRIC-SYNTHESIS; BENZYL ETHERS; N-OXIDES; ALKYLATION; ARYLATION; CATALYSIS;

D O I：

10.1016/j.tetlet.2019.05.016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An indium-catalyzed oxidative C-H alkylation and arylation of 4-substituted 3,6-dihydro-2H-pyrans (DHPs) using dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as the oxidant has been developed. The mild and modular cross-dehydrogenative coupling reaction exhibited a broad scope with respect to both DHPs and nucleophilic 1,3-dicarbonyl moieties as well as aryl rings, rapidly providing 2,4-disubstituted DHPs bearing diverse patterns of functionalities at the alpha position. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：1547 / 1550

页数：4

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