Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research

被引：10
作者：
Wang, Yazhen [1 ,2 ,3 ]
Shi, Zhen [1 ,2 ]
Sun, Yu [2 ]
Wu, Xueying [2 ]
Li, Shuang [2 ]
Dong, Shaobo [2 ]
机构：
[1] Qiqihar Univ, Coll Mat Sci & Engn, Qiqihar 161006, Peoples R China
[2] Heilongjiang Prov Key Lab Polymer Composite Mat, Qiqihar, Peoples R China
[3] Northeast Forestry Univ, Coll Chem Chem Engn & Resource Utilizat, Harbin, Peoples R China
来源：
DESIGNED MONOMERS AND POLYMERS | 2020年 / 23卷 / 01期
关键词：
Fe3O4; magnetic; Poly(vinyl alcohol); targeted drug delivery; amphiphilic; IRON-OXIDE NANOPARTICLES; FE3O4; NANOPARTICLES; CONTROLLED-RELEASE; HYDROGEL; COMPOSITE; POLYMER; SYSTEM; ASPIRIN;
D O I：
10.1080/15685551.2020.1837442
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe3O4-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe3O4 and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe3O4-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe3O4-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work's development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.
引用
收藏
页码：197 / 206
页数：10
相关论文
共 65 条
  • [11] Thiolated polymers as mucoadhesive drug delivery systems
    Duggan, Sarah
    Cummins, Wayne
    O'Donovan, Orla
    Hughes, Helen
    Owens, Eleanor
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 100 : 64 - 78
  • [12] Radiation synthesis and drug delivery properties of interpenetrating networks (IPNs) based on poly(vinyl alcohol)/methylcellulose blend hydrogels
    El-Naggar, Abdel Wahab M.
    Senna, Magdy M.
    Mostafa, Tahia A.
    Helal, Reham H.
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 102 : 1045 - 1051
  • [13] Preparation of biocompatible system based on electrospun CMC/PVA nanofibers as controlled release carrier of diclofenac sodium
    El-Newehy, Mohamed H.
    El-Naggar, Mehrez E.
    Alotaiby, Saleh
    El-Hamshary, Hany
    Moydeen, Meera
    Al-Deyab, Salem
    [J]. JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY, 2016, 53 (09): : 566 - 573
  • [14] Application of water-soluble polyvinyl alcohol-based film patches on laser microporated skin facilitates intradermal macromolecule and nanoparticle delivery
    Engelke, Laura
    Winter, Gerhard
    Engert, Julia
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2018, 128 : 119 - 130
  • [15] A therapeutic polyelectrolyte-vitamin C nanoparticulate system in polyvinyl alcohol-alginate hydrogel: An approach to treat skin and soft tissue infections caused by Staphylococcus aureus
    George, Liya
    Bavya, M. C.
    Rohan, K. Vimal
    Srivastava, R.
    [J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2017, 160 : 315 - 324
  • [16] cRGD-decorated biodegradable polytyrosine nanoparticles for robust encapsulation and targeted delivery of doxorubicin to colorectal cancer in vivo
    Gu, Xiaolei
    Wei, Yaohua
    Fan, Qianyi
    Sun, Huanli
    Cheng, Ru
    Zhong, Zhiyuan
    Deng, Chao
    [J]. JOURNAL OF CONTROLLED RELEASE, 2019, 301 : 110 - 118
  • [17] Gupta Purnima, 2019, Cardiovascular & Hematological Disorders - Drug Targets, V19, P33, DOI 10.2174/1871529X18666180508113253
  • [18] Hydrothermal growth of iron oxide NPs with a uniform size distribution for magnetically induced hyperthermia: Structural, colloidal and magnetic properties
    Gyergyek, Sao
    Makovec, Darko
    Jagodic, Marko
    Drofenik, Mihael
    Schenk, Kurt
    Jordan, Olivier
    Kovac, Janez
    Drazic, Goran
    Hofmann, Heinrich
    [J]. JOURNAL OF ALLOYS AND COMPOUNDS, 2017, 694 : 261 - 271
  • [19] Coating single-walled carbon nanotubes with tin oxide
    Han, WQ
    Zettl, A
    [J]. NANO LETTERS, 2003, 3 (05) : 681 - 683
  • [20] Design of a pH-sensitive magnetic composite hydrogel based on salecan graft copolymer and Fe3O4@SiO2 nanoparticles as drug carrier
    Hu, Xinyu
    Wang, Yongmei
    Zhang, Liangliang
    Xu, Man
    Zhang, Jianfa
    Dong, Wei
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 107 : 1811 - 1820
1234567