Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research

被引：10
作者：
Wang, Yazhen [1 ,2 ,3 ]
Shi, Zhen [1 ,2 ]
Sun, Yu [2 ]
Wu, Xueying [2 ]
Li, Shuang [2 ]
Dong, Shaobo [2 ]
机构：
[1] Qiqihar Univ, Coll Mat Sci & Engn, Qiqihar 161006, Peoples R China
[2] Heilongjiang Prov Key Lab Polymer Composite Mat, Qiqihar, Peoples R China
[3] Northeast Forestry Univ, Coll Chem Chem Engn & Resource Utilizat, Harbin, Peoples R China
来源：
DESIGNED MONOMERS AND POLYMERS | 2020年 / 23卷 / 01期
关键词：
Fe3O4; magnetic; Poly(vinyl alcohol); targeted drug delivery; amphiphilic; IRON-OXIDE NANOPARTICLES; FE3O4; NANOPARTICLES; CONTROLLED-RELEASE; HYDROGEL; COMPOSITE; POLYMER; SYSTEM; ASPIRIN;
D O I：
10.1080/15685551.2020.1837442
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe3O4-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe3O4 and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe3O4-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe3O4-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work's development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.
引用
收藏
页码：197 / 206
页数：10
相关论文
共 65 条
  • [1] Alireza H, 2019, J MAT SCI ENG C, V103, P109771
  • [2] A novel composite matrix based on polymeric micelle and hydrogel as a drug carrier for the controlled release of dual drugs
    Anirudhan, T. S.
    Parvathy, J.
    Nair, Anoop S.
    [J]. CARBOHYDRATE POLYMERS, 2016, 136 : 1118 - 1127
  • [3] RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia
    Arriortua, Oihane K.
    Insausti, Maite
    Lezama, Luis
    Gil de Muro, Izaskun
    Garaio, Eneko
    de la Fuente, Jesus Martinez
    Fratila, Raluca M.
    Morales, Maria P.
    Costa, Rocio
    Eceiza, Maite
    Sagartzazu-Aizpurua, Maialen
    Aizpurua, Jesus M.
    [J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2018, 165 : 315 - 324
  • [4] B K L, 2018, J MAGN MAGN MAT, V473, P21
  • [5] Biocompatible nanoparticles and vesicular systems in transdermal drug delivery for various skin diseases
    Carter, Prerana
    Narasimhan, Balaji
    Wang, Qun
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 555 : 49 - 62
  • [6] Highly sensitive detection of cysteine over glutathione and homo-cysteine: New insight into the Michael addition of mercapto group to maleimide
    Chen, Zhaoyang
    Sun, Qian
    Yao, Yuhua
    Fan, Xiaoxiang
    Zhang, Weibing
    Qian, Junhong
    [J]. BIOSENSORS & BIOELECTRONICS, 2017, 91 : 553 - 559
  • [7] Nanostructured lipid carriers to enhance transdermal delivery and efficacy of diclofenac
    Chien Ngoc Nguyen
    Thi Thuy Trang Nguyen
    Hanh Thuy Nguyen
    Tuan Hiep Tran
    [J]. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 2017, 7 (05) : 664 - 673
  • [8] Polyethylene glycol-coated porous magnetic nanoparticles for targeted delivery of chemotherapeutics under magnetic hyperthermia condition
    Dabbagh, Ali
    Hedayatnasab, Ziba
    Karimian, Hamed
    Sarraf, Masoud
    Yeong, Chai Hong
    Hosseini, Hamid Reza Madaah
    Abu Kasim, Noor Hayaty
    Wong, Tin Wui
    Rahman, Noorsaadah Abdul
    [J]. INTERNATIONAL JOURNAL OF HYPERTHERMIA, 2019, 36 (01) : 104 - 114
  • [9] Fabrication of low-cost composite polymer-based micro needle patch for transdermal drug delivery
    Dathathri, Eshwari
    Lal, Satyapriya
    Mittal, Mohit
    Thakur, Goutam
    De, Shounak
    [J]. APPLIED NANOSCIENCE, 2020, 10 (02) : 371 - 377
  • [10] Polymer-Lipid Hybrid Theranostic Nanoparticles Co-Delivering Ultrasmall Superparamagnetic Iron Oxide and Paclitaxel for Targeted Magnetic Resonance Imaging and Therapy in Atherosclerotic Plaque
    Dong, Yinmei
    Chen, Huaiwen
    Chen, Chao
    Zhang, Xuefeng
    Tian, Xia
    Zhang, Yingying
    Shi, Zhang
    Liu, Qi
    [J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2016, 12 (06) : 1245 - 1257
1234567