Prediagnostic circulating follicle stimulating hormone concentrations and ovarian cancer risk

被引：19

作者：

McSorley, Meghan A. ^{[2
]}

Alberg, Anthony J. ^{[2
,3
,4
]}

Allen, Diane S. ^{[5
]}

Allen, Naomi E. ^{[6
]}

Brinton, Louise A. ^{[7
]}

Dorgan, Joanne F. ^{[8
]}

Kaaks, Rudolf ^{[9
]}

Rinaldi, Sabina ^{[9
]}

Helzlsouer, Kathy J. ^{[1
,2
]}

机构：

[1] Mercy Med Ctr, Prevent & Res Ctr, Baltimore, MD 21202 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[3] Med Univ S Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA

[4] Med Univ S Carolina, Dept Bioinformat & Epidemiol, Charleston, SC 29425 USA

[5] Guys Hosp, Acad Oncol Unit, London SE1 9RT, England

[6] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[7] NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[8] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

[9] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

来源：

INTERNATIONAL JOURNAL OF CANCER | 2009年 / 125卷 / 03期

关键词：

follicle stimulating hormone (FSH); ovarian cancer; gonadotropins; epidemiology; cohort study; PROLIFERATION; EXPRESSION; WOMEN; FSH; LH;

D O I：

10.1002/ijc.24406

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gonadotropins have been indicted in ovarian carcinogenesis but direct evidence has been limited and inconsistent. The aim of this study was to determine the association between prediagnostic levels of follicle stimulating hormone (FSH) and subsequent development of invasive epithelial ovarian cancer. A nested case-control study was conducted using cases and controls drawn from three cohorts: CLUE I and CLUE II of Washington County, MD, and the Island of Guernsey Study, United Kingdom. In total, 67 Incident invasive epithelial ovarian cancer cases were each matched to 1 to 2 controls on age, menopausal status, time since last menstrual period, current hormone use and other relevant factors. FSH concentrations were classified into ranked thirds of low, medium or high based on the distribution among controls. Conditional logistic regression was used to estimate the odds ratio (OR) across increasing thirds of FSH concentrations. Results of the analysis showed that ovarian cancer risk decreased with higher FSH concentrations (p-trend = 0.005). Compared with the lowest third of FSH concentrations, the OR among those in the middle and highest thirds were 0.45 [95% Confidence Interval (CI): 0.20-1.00] and 0.26 (95% CI: 0.10-0.70), respectively. Associations persisted after excluding cases diagnosed within 5 years of follow-up. In conclusion, a reduction in subsequent risk of invasive epithelial ovarian cancer was observed among women with higher circulating FSH concentrations. These findings contradict the hypothesized role of FSH as a risk factor in ovarian carcinogenesis. (C) 2009 UICC

引用

页码：674 / 679

页数：6

共 21 条

[21] Hormone replacement therapy and ovarian cancer risk: A meta-analysis [J].

Zhou, Bo ;

Sun, Qingmin ;

Cong, Rihong ;

Gu, Haijuan ;

Tang, Naping ;

Yang, Li ;

Wang, Bin .

GYNECOLOGIC ONCOLOGY, 2008, 108 (03) :641-651

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