Survival signaling goes BAD

被引:75
作者
Bergmann, A [1 ]
机构
[1] Univ Texas, MD Anderson Canc Ctr, Dept Biochem & Mol Biol, Houston, TX 77030 USA
关键词
D O I
10.1016/S1534-5807(02)00328-3
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Work published in this issue of Developmental Cell demonstrates, in vivo, that the proapoptotic gene BAD provides a genetic link between the cell death machinery and survival signaling. This work has implications for development, tissue homeostasis, and tumorigenesis.
引用
收藏
页码:607 / 608
页数:2
相关论文
共 9 条
[1]   BCL-2, BCL-XL sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis [J].
Cheng, EHYA ;
Wei, MC ;
Weiler, S ;
Flavell, RA ;
Mak, TW ;
Lindsten, T ;
Korsmeyer, SJ .
MOLECULAR CELL, 2001, 8 (03) :705-711
[2]   Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis [J].
Datta, SR ;
Ranger, AM ;
Lin, MZ ;
Sturgill, JF ;
Ma, YC ;
Cowan, CW ;
Dikkes, P ;
Korsmeyer, SJ ;
Greenberg, ME .
DEVELOPMENTAL CELL, 2002, 3 (05) :631-643
[3]   Cellular survival: a play in three Akts [J].
Datta, SR ;
Brunet, A ;
Greenberg, ME .
GENES & DEVELOPMENT, 1999, 13 (22) :2905-2927
[4]   Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery [J].
Datta, SR ;
Dudek, H ;
Tao, X ;
Masters, S ;
Fu, HA ;
Gotoh, Y ;
Greenberg, ME .
CELL, 1997, 91 (02) :231-241
[5]  
DEL PL, 1997, SCIENCE, V278, P687
[6]   Programmed cell death in animal development [J].
Jacobson, MD ;
Weil, M ;
Raff, MC .
CELL, 1997, 88 (03) :347-354
[7]   SOCIAL CONTROLS ON CELL-SURVIVAL AND CELL-DEATH [J].
RAFF, MC .
NATURE, 1992, 356 (6368) :397-400
[8]   Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death [J].
Wei, MC ;
Zong, WX ;
Cheng, EHY ;
Lindsten, T ;
Panoutsakopoulou, V ;
Ross, AJ ;
Roth, KA ;
MacCregor, GR ;
Thompson, CB ;
Korsmeyer, SJ .
SCIENCE, 2001, 292 (5517) :727-730
[9]   Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BGL-X(L) [J].
Zha, JP ;
Harada, H ;
Yang, E ;
Jockel, J ;
Korsmeyer, SJ .
CELL, 1996, 87 (04) :619-628