Toxoplasma gondii:: Immunogenicity and protection by P30 peptides in a murine model

被引：49

作者：

Siachoque, Heber

Guzman, Fanny

Burgos, Javier

Patarroyo, Manuel Elkin

Gomez Marin, Jorge Enrique ^{[1
]}

机构：

[1] Univ Quindio, Fac Ciencias Salud, Ctr Invest Biomed, Grp Parasitol Mol,GEPAMOL, Armenia, Colombia

[2] Univ Rosario, Fac Med, Immunol Lab, Bogota, Colombia

[3] Fund Inst Immuniol, FIDIC, Bogota, Colombia

[4] Univ Distrital Francisco Jose Caldaas, Bogota, Colombia

来源：

EXPERIMENTAL PARASITOLOGY | 2006年 / 114卷 / 01期

关键词：

Toxoplasma gondii; peptides; vaccines; SAG1; P30; murine model;

D O I：

10.1016/j.exppara.2006.02.005

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Vaccines are promising for the control of toxoplasmosis. Here, we evaluated the immunogenicity of 17 peptides derived from SAG1 surface protein of Toxoplasma gondii in CH3 mice. Only 8 of 16 peptides induced specific antibodies. After a lethal challenge, only the vaccination with 4 of 17 peptides that were from the carboxy terminal end of the protein conferred significant survival. Our work shows that vaccination with peptides from the carboxy-terminal positions of SAG1 major surface protein of Toxoplasma protects mice against a lethal challenge. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：62 / 65

页数：4

共 14 条

[1] The conformation of purified Toxoplasma gondii SAG1 antigen, secreted from engineered Pichia pastoris, is adequate for serorecognition and cell proliferation [J].