A mitochondria-targeted fluorescent probe for ratiometric detection of endogenous sulfur dioxide derivatives in cancer cells

被引：174
作者：
Li, Dong-Peng [1 ]
Wang, Zhao-Yang [2 ]
Cao, Xiang-Jian [1 ]
Cui, Jie [1 ]
Wang, Xin [1 ]
Cui, Hao-Zhong [1 ]
Miao, Jun-Ying [2 ]
Zhao, Bao-Xiang [1 ]
机构：
[1] Shandong Univ, Inst Organ Chem, Sch Chem & Chem Engn, Jinan 250100, Peoples R China
[2] Shandong Univ, Inst Dev Biol, Sch Life Sci, Jinan 250100, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 13期
基金：
中国国家自然科学基金;
关键词：
LIVING CELLS; IN-VIVO; HYDROGEN-SULFIDE; SO2; DERIVATIVES; SERUM SULFITE; PHOSPHORESCENT PROBE; SELECTIVE DETECTION; SENSING MECHANISM; AQUEOUS-SOLUTION; RAPID DETECTION;
D O I：
10.1039/c5cc09092j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new mitochondria-targeted fluorescent probe HCy-D, constructed by dansyl and hemicyanine fluorophores, for SO2 derivatives (HSO3-/SO32-) was presented. This probe was designed based on a new FRET platform. HCy-D showed a ratiometric, sensitive and rapid response to HSO3-/SO32-. Importantly, HCy-D was successfully used for fluorescence imaging of endogenous bisulfite in HepG2 cells, which may benefit cancer diagnosis by discriminating liver cancer cells from normal liver cells.
引用
收藏
页码：2760 / 2763
页数：4
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